Therapeutic drug monitoring characteristics in a tertiary university hospital in 2019

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dc.authorid0000-0002-3060-1507en_US
dc.authorid0000-0002-2998-263Xen_US
dc.contributor.authorÖzünal, Zeynep Güneş
dc.contributor.authorİpek, Belkız Öngen
dc.date.accessioned2024-07-12T21:43:18Z
dc.date.available2024-07-12T21:43:18Z
dc.date.issued2020en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractIntroduction Therapeutic drug monitoring (TDM) is defined as measuring drug concentration in a biological sample to optimize pharmacotherapy. This study aims to evaluate TDM requests in a tertiary university hospital retrospectively. Materials and methods TDM requests were evaluated retrospectively for lithium, valproic acid, carbamazepine, and digoxin in 2019. The age and gender of the patient, requesting department, and measurement results were evaluated. Lower levels than the reference values were considered as subtherapeutic, while levels higher than the reference were considered as toxic. Results A total of 415 drug level measurement records were found. The pediatric age sample ratio was 13.7%, and the elderly age sample ratio was 11.8%. When all samples were evaluated according to the relevant laboratory cut-off values, 72.8% of samples were within the therapeutic level range, 21.9% of samples were subtherapeutic, and 5.3% were toxic. The pediatric age group had a higher ratio of toxic levels for the four drugs studied (54.5%). Conclusions Tests for lithium, valproic acid, carbamazepine, and digoxin would not be considered sufficient for TDM. Multidisciplinary teamwork might be appropriate for further implementation and interpretation of TDM.en_US
dc.identifier.citationÖzünall, Z. G. ve İpek, B. Ö. (2020). Therapeutic drug monitoring characteristics in a tertiary university hospital in 2019. Cureus, 12(4).en_US
dc.identifier.doi10.7759/cureus.7612
dc.identifier.issn2168-8184
dc.identifier.issue4en_US
dc.identifier.pmid32399346en_US
dc.identifier.urihttps://doi.prg/10.7759/cureus.7612
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7573
dc.identifier.volume12en_US
dc.identifier.wosWOS:000525180400002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCureus Inc.en_US
dc.relation.ispartofCureusen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00579
dc.subjectBiochemistryen_US
dc.subjectCarbamazepineen_US
dc.subjectDigoxinen_US
dc.subjectLithiumen_US
dc.subjectPharmacologyen_US
dc.subjectTherapeutic drug monitoringen_US
dc.subjectValproic aciden_US
dc.titleTherapeutic drug monitoring characteristics in a tertiary university hospital in 2019en_US
dc.typeArticle
dspace.entity.typePublication

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