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Erişkin çağı pnömokok aşılamalarının COVID-19 klinik seyri ile ilişkisi / The relationship between adult pneumococcal vaccination and the clinical course of COVID-19
(T.C. Maltepe Üniversitesi, 2024) Sur Ünal, Ülkü
Sayın Editör, Derginizin Ağustos 2024’te yayınlanan sayısında Karaçepiş ve ark. tarafından yürütülmüş olan ve yayınlanan "COVID-19 pandemisinin önerilen erişkin aşılamalara etkisi: Hastane temelli çalışma" başlıklı makaleyi büyük bir ilgiyle okudum (1). Sayın yazarlara çalışmaları için çok teşekkür ediyorum. Bu çalışma, COVID-19 pandemisinin erişkin aşılamaları üzerindeki etkilerini ele alarak önemli bulgular ortaya koymaktadır. Özellikle pnömokok aşılamasındaki artış, COVID-19 pandemi döneminin ilginç sonuçlarından biridir. İlgili makalenin tartışma bölümünde bahsedilen, COVID19 pandemi döneminde pnömokok aşısının COVID19'dan koruyacağına dair yayılan bilgilere dikkat çekmek istiyorum. Bu bilgi, o dönemde özellikle halk arasında yaygınlaşmış ve pnömokok aşısına olan talebi artırmıştır. Ancak, bu konuda var olan bilimsel literatürü irdelemenin ve destekleyici veri sunmanın önemli olduğunu düşünüyorum. Bunun yanında makalede bahsi geçen pnömokok aşısının, özellikle belirtilmediği için tam emin olamamakla birlikte, 13 valanlı konjuge pnömokok aşısı (PCV13) olduğunu; uygulanan pnömokok aşılarının içinde polisakkarit pnömokok aşılarının yer almadığını tahmin ediyorum. Bunun yanında her ne kadar PCV13’ün dışında PCV15 ve PCV20 konjuge pnömokok aşıları bulunsa da ülkemizde henüz PCV15 ve PCV20 bulunmamaktadır (2). Yaygın kullanımı nedeniyle bu konu hakkında yapılan çalışmaların çoğunun PCV13 üzerine yapılmış olduğu görülmektedir.
Katarakt cerrahisi sonrası her iki gözde kistoid maküler ödem / Cystoid macular edema in both eyes after cataract surgery
(T.C. Maltepe Üniversitesi, 2024) Çağlar, Çağatay; Erkaya Küçükkömürcü, Elvan
Psödofakik kistoid makula ödemi, komplikasyonsuz katarakt cerrahisini takiben en sık görülen komplikasyonlardan biridir. Çoğu vakada, macula ödemi iyi huyludur, kendi kendini sınırlar ve görme bozukluğu olmadan kendiliğinden düzelir; ancak, dirençli kistoid ödem ve inatçı vakalar ortaya çıkabilir ve görme keskinliğini azaltabilir.
Proksimal özofagusta inlet patch / Inlet patch in proximal esophagus
(T.C. Maltepe Üniversitesi, 2024) Aytekin, Velat; Yüksekyayla, Osman; Uyanıkoğlu, Ahmet
İnlet Patch (IP), heterotropik gastrik mukozanın konjenital olarak servikal özofagusta görülmesidir. IP, özofagogastroduodenoskopi sırasında tesadüfen tespit edilmekle birlikte sıklıkla disfaji, odinofaji, kalıcı globus hissi, midede yanma, şişkinlik, gaz ve bazen ağza acı, ekşi su gelmesi semptomları ile prezente olabilir. Bu yazıda nadir görülen servikal inlet patch olgusu literatür eşliğinde sunulmuştur.
Obsessive skincare and liver toxicity: A case report on titanium dioxide exposure / Obsesif cilt bakımı ve karaciğer toksisitesi: Titanyum dioksit maruziyeti üzerine bir olgu sunumu
(T.C. Maltepe Üniversitesi, 2024) Kaya, Fatih Öner; Abunawas, Mohammad Jamal; Mert, Pınar
This Case Report highlights the role of titanium dioxide (TiO2) as a perpetrator of liver toxicity when used topically. Although the European Commission has banned titanium dioxide (E171) from being used as a food additive, it is still widely used in dermatological products. Here, we describe a patient who initially presented to our clinic after experiencing a seizure. An inquiry into her history revealed that she had been suffering from generalized body aches and skin rashes for the past month. Incidentally, liver enzymes were found to be significantly elevated, and abdominal ultrasonography revealed hepatomegaly and hepatic steatosis, which was confirmed by a liver biopsy. Further investigation brought to light the patient’s obsessive skincare habits, requiring broader tests to detect any toxic exposure. Thereupon, high amounts of titanium were found in her blood results. TiO2 particles are associated with hazardous properties and pose a threat to human health and the environment; thus, its enormous usage in various products requires further studies that investigate the various ways of exposure to minimize those toxic effects.
The efficacy of topical vitamin A in allergic conjunctivitis - case control research / Allerjik konjonktivitte topikal A vitaminin etkinliği- olgu kontrol araştırması
(T.C. Maltepe Üniversitesi, 2024) Erdoğan, Hakika; Akingöl, Ziya; Taş, Kardelen
Aim: The aim of this study is to evaluate the efficacy of topical vitamin A ointment (retinol palmitate, 250 IU/g) on the comfort of for the patients with symptomatic allergic conjunctivitis and dry eye. Material and Methods: 93 patients with seasonal and perennial allergic conjunctivitis were enrolled in this study. We prescribed topical vitamin A ointment and the classic ocular allergy treatment to 47 and classic ocular allergy treatment only to 46 (control group) patients, respectively. Patients’ ocular allergy and dry eye signs and symptoms were compared before and after the treatment in each group. Results: The topical vitamin A treatment and control groups led to significant improvement in the ocular examination in terms of ocular surface disease index (OSDI) scores and breakup time (BUT) values, but the results were comparatively better in the vitamin A group. We observed the results of the Oxford scheme for the corneal surface condition, and the main symptoms and the other findings of ocular allergy had improved in both the groups after the treatment, without significant differences between the groups. Conclusion: Our findings suggest that the adjunct treatment with topical vitamin A is effective for allergic conjunctivitis accompanied by dry eye symptoms.
Analysis of external ear morphometry in university students / Üniversite öğrencilerinde dış kulak morfometrisinin analizi
(T.C. Maltepe Üniversitesi, 2024) Gurlek Celik, Nihal
Aim: We aim to obtain data for our society by comparing the auricula's right and left morphometric measurements according to sex and side. Material and Methods: Our study was conducted with the voluntary participation of 60 healthy individuals (30 female, 30 male) between the ages of 18 and 26 studying at Amasya University Health Services Vocational School. Ear measurements of individuals with no anomalies related to the outer ear and who had not undergone surgery or trauma were made using a digital carbon fiber caliper. The measurement results were stated in mm. Results: The right PAL, PAW, and MAL measurement results and the left PAL and PAW measurement results of males were statistically higher than those of females. Other parameters were not statistically different in males and females. The variables' right and left side values were not statistically different in the whole group, in males and females. Conclusion: We believe that knowing the dimensions of the auricula will be important in surgical procedures and in determining sex and identity.
Acil servis hemşirelerinde merhamet yorgunluğunun bakım verici rollerine olan etkisi: Bir şehir hastanesi anket çalışması / The effect of compassion fatigue on caregiving roles of emergency nurses: A city hospital survey study
(T.C. Maltepe Üniversitesi, 2024) Başoğlu, Sümeyye; Aktaş, Nurhan; Otal, Yavuz
Amaç: Bu araştırma acil serviste çalışan hemşirelerin merhamet yorgunluğu ve bakım verici rolleri arasındaki ilişkiyi belirlemek amacıyla planlanmıştır. Materyal ve Metodlar: Tanımlayıcı ve kesitsel tipteki bu çalışma, Türkiye’deki bir şehir hastanesinde görev yapan 135 hemşire ile gerçekleştirilmiştir. Araştırmanın verileri, “Hemşire Bilgi Formu”, “Merhamet Yorgunluğu Kısa Ölçeği” ve “Hemşirelerin Bakım Verici Rollerine İlişkin Tutum Ölçeği” aracılığı ile toplanmıştır. Verilerin değerlendirilmesinde t testi, varyans analizi ve Pearson Korelasyon Testi kullanılmıştır. Bulgular: Araştırmada, hemşirelerin Merhamet Yorgunluğu Kısa Ölçeği toplam puan ortalaması 58.42±20.44, Hemşirelerin Bakım Verici Rollerine İlişkin Tutum Ölçeği toplam puan ortalaması 64.26±8.26 olarak bulunmuştur. Hemşirenin Bakım Verici Rolüne İlişkin Tutum Ölçeği ve Merhamet Yorgunluğu Kısa Ölçeği ve alt boyutları arasında istatistiksel olarak anlamlı bir ilişki olmadığı saptanmıştır. Hemşirelerin eğitim durumu, evli olma, çocuk varlığı, çalışma süresi, mesleği isteyerek seçme, başka birime geçmeyi düşünme ve işten ayrılmayı düşünme durumunun merhamet yorgunluğunu etkilediği belirlenmiştir. Sonuç: Hemşirelerin bakım verici rollerine ilişkin tutumlarının arttırılması için merhamet yorgunluğunun azaltılmasına yönelik danışmanlık, psikolojik destek müdahalelerin ve meslek gelişim programların planlanması önerilmektedir.
Evaluation of the dermatological quality of life of children diagnosed with atopic dermatitis and their mothers / Atopik dermatit tanısı olan çocukların ve annelerinin dermatolojik yaşam kalitesinin değerlendirilmesi
(T.C. Maltepe Üniversitesi, 2024) Altaş, Zeynep Meva; Altas, Uğur; Özkars, Mehmet Yaşar
Aim: This study aimed to evaluate the dermatologic quality of life of children with atopic dermatitis and their mothers. Material and Methods: 38 children with the diagnosis of atopic dermatitis and their mothers were included in this cross sectional type of study. The clinical severity of atopic ÖZET Amaç: Bu çalışmada atopik dermatitli çocukların ve annelerinin dermatolojik değerlendirilmesi amaçlanmıştır. yaşam kalitelerinin Materyal ve Metodlar: Kesitsel tipteki bu çalışmaya atopik dermatitis was classified with the SCORAD index. The questionnaire “The Children's Dermatology Life Quality Index (CDLQI)” was filled by the mothers to evaluate the dermatological quality of life of the children. In addition, the “Dermatology Life Quality Index (DLQI)” was applied to the mother. The age, gender, laboratory values of the children, mothers' age were examined in addition to dermatologic life quality. P<0.05 was accepted as statistical significance level. Results: Fifteen (39.5%) of 38 children with atopic dermatitis were girls and 23 (60.5%) were boys. The median age of children and mothers were 7.0 years (5.016.0) and 38.0 years (26.0-52.0), respectively. Of the children 52.6% had moderate atopic dermatitis. The median scores of CDLQI and DLQI were 12.0 (1.0-29.0), 15.0 (1.0-27.0), respectively. The median score of CDLQI with moderate/severe atopic dermatitis was significantly higher (p <0.001). Multiple allergen sensitivity and gender had no significant effect on CDLQI scores (p>0.05). Conclusion: The dermatological quality of life of children with moderate-severe atopic dermatitis impaired more. With the clinical control of the disease, the dermatological quality of life could also be increased.
Development of chondroblastic variant of osteosarcoma after root channel treatment in the base of maxillary sinus
(Georg Thieme Verlag, 2024) Balsak, Serdar; Yabul Çelik, Fatma; Atasoy, Bahar; Yurtsever, Ismail; Yozgat, Can Yilmaz; Akcay, Ahmet; Yuzkan, Sabahattin; Alkan, Alpay
A 21-year-old patient was admitted to the department of otolaryngology with complaints of swelling over the right side of the upper jaw for the last 6 past months. The patient also has difficulty in mastication as the size of the swelling had increased. The patient dental history was notorious for root canal treatment in the second molar tooth prior to the initiation of the swelling. The patient did not have any other illnesses and did not have any family history of malignancy. Of note, the patient did not have any notable addictions. The patient did not have any distant metastatic symptoms, and no other significant history of swellings anywhere else in his body. Physical examination in the department of otolaryngology revealed that around the second molar root expansible, rigid lesion was detected. Thus, the department of radiology was consulted and according to the patient’s maxilla-facial computed tomography (CT) showed that there was a 30×25 mm lesion in the nearby of the 2nd molar tooth. Also, the lesion resulted in bone destruction in the maxillary sinus base of the patient. The lesion in the center had diffused calcifications inside of the mass spreading throughout the maxillary sinus to retro molar trigon. Due to the central calcification content in the central of the lesion, the possibility of osteogenic tumour was thought ([Fig. 1]). To learn the contrast pattern of the lesion, contrasted maxilla-facial MRI was requested. According to the T2W sequence demonstrated that there was an increase in peripheral hyper intensity around the calcification lesion. Contrasted sequences revealed that demarcated thin peripheral and a central nodular enhancement was observed. The other parts of the imaging did not show any abnormalities ([Fig. 2]). A core needle biopsy was performed through intraoral route and the result of the biopsy report demonstrated that there was a cartilage tumour containing irregular lobulated areas. New bone formation was noted in areas compatible with the osteoid. There were many atypical looking chondroblastic variant of osteosarcoma cells. The result of pathological specimen was compatible with chondroblastic variant of osteosarcoma. Later, the patient was planned for mass excision.
Slx5/Slx8 SUMO-targeted ubiquitin ligase deficiency shortens lifespan due to increased mutation accumulation in yeast
(Oxford University Press, 2024) Thomas, Pınar Buket; Kaluç, Nur; Çavli, Irmak N.; Tuna, Bilge G.
Chronological lifespan (CLS) in budding yeast Saccharomyces cerevisiae, which is defined as the time nondividing cells in saturation remain viable, has been utilized as a model to study post-mitotic aging in mammalian cells. CLS is closely related to entry into and maintenance of a quiescent state. Many rearrangements that direct the quiescent state enhance the ability of cells to endure several types of stress. SUMO-targeted ubiquitin ligases (STUbLs) play a critical role in mediating an adaptive response to various stresses. In this study, we investigated the effect of a STUbL, Slx5/Slx8, on CLS in budding yeast. We showed that both SLX5 and SLX8 deletions accelerate chronological aging, resulting in a decreased maximum and mean lifespan. slx5Δ cells were capable of entering or maintaining a quiescent state during aging. On the other hand, aging slx5Δ and slx8Δ cells had both increased spontaneous mutation accumulation. Our data together indicate that Slx5/Slx8 STUBL is required for normal rate of aging by preventing increased spontaneous mutation accumulation during aging.
Intraoperative diaphragmatic stimulation by a cardiac resynchronization therapy defibrillator presenting as hiccups
(Springer Nature, 2024) Aybar, Hüseyin
Pacemaker-related diaphragmatic contractions are a phenomenon encountered in cardiology practice. With informed consent from the patient, this letter reports a case of this condition under general anesthesia, presenting as hiccups. A 44-yr-old female patient with a history of back pain was diagnosed with lumbar stenosis and presented for posterior instrumentation surgery. She had a height of 163 cm and weight of 104 kg; her known comorbidities included obesity (body mass index [BMI], 39.1 kg m-2), type 2 diabetes, and nonischemic dilated cardiomyopathy with a left bundle branch block and an implanted cardiac resynchronization therapy–defibrillator (CRT-D) device (INOGENTM X4 CRT-D model G148, Boston Scientific Corporation, Marlborough, MA, USA). General anesthesia (GA) was induced, the patient wa positioned prone, and neuromonitoring was initiated.Intravenous infusions of propofol and remifentanil were initiated for maintenance of GA. Preoperatively, a cardiologist reprogrammed the CRT-D device; the pacing mode was kept the same to ensure left ventricle (LV) functionality and tachycardia therapy was deactivated (even though magnet application effects on the device are the same as those of the abovementioned configuration, the prone position would have hindered the ability to maintain the position of the magnet).
Associations between stages of diabetic polyneuropathy and quality of life, neuropathic pain, and well-being: A multicenter, cross-sectional analysis based on electroneuromyographic findings
(Elsevier, 2024) Kılıçparlar Cengiz, Emine; Ekmekyapar Fırat, Yasemin; Karşıdağ, Sibel; Neyal, Abdurrahman; Erdemoglu, Ali Kemal; Çınar, Nilgün; Ekmekyapar, Tuba; Canbaz Kabay, Sibel; Akkoyun Arıkan, Fatma; Akdağ, Gonül; Çomruk, Gülsüm; Ates, Miruna; Kendirli Aslan, Sude; Çokal, Burcu Gökçe; Tosunoglu, Bünyamin; Bolu, Naci Emre; Yanık, Ece; Savrun, Feray; Tülek, Zeliha; Kılıçaslan, Kimya; Çakar, Egemen Kaan; Ergin Bakar, Ebru; Atmaca, Murat Mert; Yılmaz, Buket; Neyal, Ayşe Münife
Aim: This study aimed to investigate the relationship between electrophysiological findings of diabetic neu ropathy (DN) and patients’ quality of life, neuropathic pain levels, and well-being. Materials and Methods: A cross-sectional study was conducted in 12 centers in Turkey. DN patients were cate gorized into four stages based on electrophysiological findings using the Baba classification. Scales such as Short Form-36 (SF-36), Douleur Neuropathique 4-Questions (DN4), Brief Pain Inventory (BPI), and WHO-5 Well-Being (WHO-5 WB) were used to assess quality of life, pain, and well-being. Additional factors like HbA1c levels and diabetes duration were analyzed. Results: Among 323 DN patients, 90 were in stage 1, 84 in stage 2, 72 in stage 3, and 77 in stage 4. There were no significant differences in age or gender between the stages. Diabetes duration and HbA1c levels were signifi cantly lower in stage 1 compared to later stages. SF-36 and WHO-5 WB scores declined, while DN4 and BPI pain interference scores increased in the later stages. These findings persisted after adjusting for confounders such as age, BMI, comorbidities, and diabetes duration. Conclusion: Patients with advanced-stage DN experienced a poorer quality of life, greater pain, and more frequent comorbidities compared to early-stage patients. Electrophysiological findings should be considered in the clinical management of DN.
Investigation of the effects of blocking potassium channelswith 4-aminopyridine on paclitaxel activity in breastcancer cell lines
(Wiley, 2024) Cüce Aydoğmuş, Esra Münire; İnhan Garip, Günseli Ayşe
Background: Paclitaxel (PTX) has been used as a chemotherapeutic agent for several malignancies, including breast cancer, and efforts to increase the efficiency of PTX are continuous. Previous studies have shown that the voltage-gated K+ channels are over-expressed in breast cancer cell lines; therefore, blocking this type of K+ channel reduces cell proliferation and viability. Aims: In this study, FDA-approved 4-aminopyridine (4-AP), a voltage-gated potassium channel blocker, was used in combina tion with PTX to improve the anticancer activity of PTX in MCF-7 and MDA-MB-231 cell lines. Methods and Results: Viability was determined with trypan blue, a clonogenic assay was performed, and the cell cycle was determined with a flow cytometer and immunochemistry. To gain an insight into the mechanism, intracellular K+ concentration, intracellular Ca2+ (calcium) concentration, and transmembrane potential measurements were made with corresponding fluo rescent dyes. The apoptotic cell number was determined using Annexin /PI method by flow cytometer. Viability decreased with combination therapy and the clonogenic assay proved decreased colony formation. The apoptotic cell number was increased after treatment with the combination in both cell lines. Cell cycle measurements showed G1 arrest for both MCF-7 and MDA-MB-231 cell lines upon 4-AP treatment. PTX caused G1 arrest in MCF-7 cells and S phase arrest in MDA-MB-231 cells. Combination treatment caused S phase arrest in MCF-7 cells and S phase and G2/M phase arrest in MDA-MB-231 cells. Intracellular K+ con centration was increased after all treatments in both cell lines. Ca2+ concentration was increased significantly after combination treatment. Depolarization in the transmembrane potential was observed after all treatments in both cell lines. Conclusion: Biophysical parameters like the transmembrane potential and ion fluxes have been defined in cancer progression which can provide new aspects for cancer treatments. This study shows that the combination of 4-AP with PTX is a promising alternative the mechanism of which needs further investigation considering the results obtained for Ca2+, K+, and membrane potential.
Molecular markers in embryo non-development: Analysis of gene expressions (Ki-67, hTERT, HIF-1α) in spent embryo culture medium
(Licensee MDPI, 2024) Kılıç, Nergis Özlem; Kütük, Duygu; Öner, Çağrı; Aslan Öztürk, Senem; Selam, Belgin; Çolak, Ertuğrul
An embryo culture medium is a specialized set of ambient conditions, technological equipment, and nutrients that embryos require to grow properly. We aimed to investigate the Ki-67, hTERT, and HIF-1α gene expression differences between developing and non-developing embryos in spent embryo culture medium. Ki-67, hTERT, and HIF-1α gene expressions were determined from the spent embryo culture medium containing developing and non-developing embryos of 20 normoresponder patients admitted to the Bahçeci Umut IVF Center. An increase in hTERT gene expression (p < 0.05) and a decrease in HIF-1α gene expression (p < 0.001) were observed in mediums of developing compared to the non-developing embryos. No difference was observed in Ki-67 gene expression (p > 0.05). While there was a correlation between Ki-67 and HIF-1α genes in the non-growing group (r < 0.01); no correlation was observed in the developing group (r > 0.05). Both normoresponder groups will be similar in terms of proliferation rate. The low HIF-1α expression that observed high telomerase activity in embryo development maintains continuity and avoids mechanisms that result in cell death. A molecular study of the embryo development in patients with similar characteristics may help to understand the pathogenesis of the disease and establish a diagnosis and specific treatment.
Long terms results of temporal facelift: 6 years of experience in 250 cases
(Lippincott Williams & Wilkins Ltd., 2024) Şirinoğlu, Hakan; Tatar, Burak Ergün; Güvercin, Emre
Background: Temporal facelift (TFL) is an innovative technique for lifting the upper and mid-face. It is characterized by a unique dissection plane above the subgaleal fascia, which seamlessly transitions into the sub-superficial muscular apo neurotic system (SMAS) layer in the mid-face. This approach enables comprehensive mid-face elevation, robust canthopexy, and a significant brow lift in various vectors. Objectives: The authors present their experience with 250 TFL procedures over a period of 6 years. Patients and Methods: This retrospective study analyzed 250 of 441 patients who underwent TFL surgery. The surgical proce dures, conducted under general anesthesia by a senior surgeon following the TFL method, involved a vertical-vector deep-plane mid-face lift, canthopexy, and brow-lift triad. Close monitoring of complications and detailed photographic documentation of the outcomes were performed. Postoperative care included taping the operation area to reduce swelling, with subsequent follow-up examinations and interventions such as lymphatic massage and botulinum toxin injections for asymmetric brow movements or steroid injections for excessive mid-face swelling. Results: Among 250 patients (248 female, 2 male; mean age, 37 y), unilateral neuropraxia of the frontal branch of the facial nerve occurred in 5.6% and resolved spontaneously within 2.8 months. Persistent dimples (2.8%) resolved by the fifth postoperative month. Six patients (2.4%) underwent revision surgery with no observed complications like hematoma, ne crosis, infection, or seroma. Conclusions: The TFL technique represents a significant ad vancement in upper and mid-face lifting procedures and offers several advantages over the traditional methods.
The association of piR-651 and piR-823 on metastaticand invasive characteristics of triple negative breastcancer cells
(Taylor & Francis Group, 2024) Öner, Çağrı; Köser, Faruk; Çolak, Ertuğrul
PIWI-Interacting RNAs are small non-coding RNAs derived fromsingle-stranded RNAs which plays a crucial role in epigeneticregulation through transposon silencing and mRNA degrada-tion via deamination. This study aimed to inhibit piR-651 andpiR-823 in MDA-MB-231 triple-negative breast cancer cells andto explore their potential effects on healthy HUVEC cells. Non-target, anti-piR-651, and anti-piR-823 sequences were trans-fected in bothHUVEC and MDA-MB-231 cells usingLipofectamine. Proliferation and motility were assessed at 24,48, and 72 h post-transfection in both cell lines. Based on themotility findings, MDA-MB-231 cells were underwent an inva-sion assay using crystal violet staining. The expressions of Ki-67,HIF-1α, MMP-2, and MMP-9 genes were measured at 48 h,when both cell lines exhibited the most significant effects ofinhibition. The optimal time for proliferation of anti-piR-651 andanti-piR-823 transfected MDA-MB-231 cells was determined tobe at 48 h, as indicated by decreased motility and invasionassay results (p < 0.001). NeverthelessHowever, there was no sig-nificant difference in the motility and proliferation of HUVECsstransfected with anti-piR-651 and anti-piR-823 compared to thecontrol group (p > 0.05). Asides from MMP-2 in anti-piR-823transfected HUVECs and HIF-1α in anti-piR-823 transfectedMDA-MB-231 cells, gene expressions of Ki-67, HIF-1α, MMP-2,and MMP-9 were reduced in both cell lines (p < 0.001). Inhibitionof piR-651 and piR-823 decreased the survival and metastasisof cancer cells, without causing vital structural changes inhealthy cells. Future research in cancer gene therapy or geneticmodification may benefit from investigating piR-651 and piR-823 as possible inhibitors of breast cancer invasion andmetastasis.
Yeni yumurta-tavuk paradoksu: Sirkadiyen ritim ya da yaşam stili mi? Son hücre düzenleyici hangisidir? / The new egg-chicken paradox: Circadian rhythm or lifestyle? Which is the last cell editor?
(T.C.Maltepe Üniversitesi, 2023) İzmirli, Müzeyyen
Bedenimizde, yaklaşık 24 saatlik, otonom bir mekanizma tarafından düzenlenen, zamana bağlı döngüsel çalışan bir sistem vardır ve bu sistem sirkadiyen saat ya da sirkadiyen ritim olarak adlandırılır. Bu ritim uyku-uyanıklık, vücut ısısı, hormonların salgılanması, lokomotor aktivite ve iştah gibi çeşitli fizyolojik işlevlerin günlük rutinler halinde devam etmesini sağlar. Diğer taraftan, yapılan son çalışmalar yenilen yemeğin kalitesinin, içeriğinin (protein, karbonhidrat ya da yağ ağırlıklı olabileceği gibi, vitamin, mineral ve gıda katkı maddeleri gibi), zamanlamasının (öğün aralıkları, aydınlık ve karanlık süreçlerde yemek yeme), günlük yaşamımızdaki egzersiz ve uyku kalitesinin sirkadiyen metabolizmayı belirgin şekilde değiştirdiğini rapor etmiştir. Bireyin beslenme alışkanlıkları, enerji metabolizması, sirkadiyen saat, bedenin ritmi bir arada değerlendirildiğinde ortaya karışık bir metabolik yolak ağı çıkıyor. Bu yüzden, bu derlemede yaşam stili ve özellikle diyet kompozisyonu, uyku ve egzersiz açısından bakıldığında, sirkadiyen saatin ve bedenin ritminin, moleküler hücresel süreçleri ile genetik ve epigenetik temelinin aydınlatılması amaçlanmıştır.
Pulmonary Hydatid Cyst: Pathophysiology, etiopathogenesis, diagnosis and treatment / Pulmoner Hidatik Kist: Patofizyoloji, etiyopatogenez, tanı ve tedavi
(T.C. Maltepe Üniversitesi, 2023) Kılıççalan, İbrahim; Cingöz, Orhun Tunahan
Aim: Echinococcosis is a parasitic disease caused by cestodes of the genus Echinococcus, which often affects the liver and lungs. Pulmonary hydatid cysts are often transmitted in childhood and remain asymptomatic for a long time. As a result, the diagnosis is often incidental in noncomplicated cases. In some cases hydatid cysts may rupture and in this occurrence it is then called a complicated cyst. When a complicated pulmonary hydatid cyst occurs, various symptoms such as chest pain, shortness of breath, cough, and hemoptysis may be observed. For diagnosis radiologic methods and serologic tests may be used. The most commonly used radiological method for pulmonary hydatid cysts is chest radiography. Echinococcosis can be treated pharmacologically with medications under certain situations; nonetheless, surgical treatment is the gold standard. Pharmacological treatment includes benzimidazole group drugs such as albendazole and in surgical treatment, various techniques such as enucleation, pericystectomy, capitonated cystotomy are applied.
Meme koruyucu cerrahi sonrası radyoterapiye bağlı sekonder gelişen skuamöz hücreli kanser: Bir olgu sunumu / Squamous cell cancer developing secondary to radiotherapy after breast conserving surgery: A case report
(T.C. Maltepe Üniversitesi, 2023) Maden, Miray; Isgandarov, Ulvi; Eruyar, Ahmet Tuğrul; Utkan, Nihat Zafer
Radyasyon tedavisi, meme kanseri için genel olarak kabul görmüş bir tedavi seçeneğidir. Meme koruyucu cerrahi sonrası adjuvan radyoterapi uygulanan hastalarda nadiren sekonder malignite gelişebilir. Bu yazımızda radyoterapi tedavisi sonrası sekonder skuamöz hücreli kanser gelişen olgumuzu sunmayı amaçladık.
Role of presepsin in predicting sepsis and mortality in COVID-19 pneumonia / Presepsinin COVID-19 pnömonisinde sepsis ve mortaliteyi öngörmedeki rolü
(T.C. Maltepe Üniversitesi, 2023) Siber, Veysi; Siber, Hatice Kübra; Aysin, Murat; Güler, Sertaç; Özbaş Demirel, Özlem; Dereyurt, Dursun Buğra; Erdaş, Sümeyye; Otal, Yavuz; Günaydın, Yahya Kemal; Okumuş, Mehmet
Aim: Aim: We aimed to investigate the prognostic significance of Presepsin (PSP) in patients with Coronavirus Disease 2019 pneumonia who were admitted to the emergency department (ED). Material and Methods: This study was conducted as a prospective, case-controlled, observational study. 123 patients with a diagnosis of Covid-19 pneumonia were chosen for the case group and 123 volunteers were enrolled as a control group. 62 of the patients were classified into the sepsis group and 61 patients were placed into the non-sepsis group. The follow-up and treatment of the patients were carried out according to the Covid19 Severe Pneumonia, ARDS, Sepsis, and Septic Shock Management Guideline of the Türkiye Ministry of Health. The PSP level was studied in patients with and without sepsis diagnosed with Covid-19 pneumonia. Results: There was no statistically significant difference between the control group, the sepsis group, and the non-sepsis group when the PSP values were compared. However, when the ROC curve was studied for the case group, a statistically significant difference between the survivors and non-survivors was discovered (p<0.05). Conclusion: No statistically significant distinction in PSP values between the control group and the septic and non-septic patient groups with Covid-19 pneumonia was found. However, PSP values were shown to be statistically significant in mortality of Covid-19 pneumonia and survival.

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