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Yayın Seroepidemiology of hepatitis viruses, measles, mumps, rubella and varicella among healthcare workers and students: Should we screen before vaccination?(ELSEVIER SCIENCE LONDON, 2020) Karadeniz, Asli; Alasehir, Elcin AkdumanBackground: Health care workers (HCWs) and students are at increased risk for blood borne infections and vaccine preventable diseases (VPDs). The aim of this study was to determine the seroprevalence of antibodies against measles, rubella, mumps, varicella zoster virus (VZV), hepatitis A and B viruses among HCWs and students and to determine whether there are differences according to gender and age group. Methods: Information about characteristics of the 1053 participants, history of disease and vaccination status were collected using a structured questionnaire. Serum samples were tested for antibodies by commercial immunoenzymatic assays. Results: Seropositivity rates were 57.1% for measles, 74% for mumps, 96.3% for rubella, 93.7% for VZV, 33.9% for hepatitis A virus and 92.2% for hepatitis B virus. Susceptibility rates among participants 18-26, 27-38 and >38 years of age were statistically significant for measles (46%, 18.6% and 0%; p < 0.001) and mumps (27.1%, 12.9% and 21.4%; p < 0.05), respectively. Conclusion: Low seropositivity rates for measles, mumps and HAV are important findings. For other diseases other than VZV, it is thought that vaccination without pre-screening is more appropriate. Healthcare institutions should have policies for screening and vaccination of their staff and students. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.Yayın Xanthogranulomatous cystitis: a challenging imitator of bladder cancer(SPRINGER, 2009) Ekici, S.; Ekici, Dogan A., I; Midi, A.; Eroglu, A.; Ruacan, S.…Yayın Attachment-based psychosocial programme for under-privileged school children with adverse life experiences in Istanbul, Turkey(Springer, 2022) Warfa, Nasir; Karasar, Şahin; White, RobertChildren experiencing educational neglect are likely to experience the harm associated with adverse life experiences and a range of emotional and psychological challenges. Using attachment theory and psychosocial frameworks, we devised and implemented an intervention designed to ameliorate the deleterious efects of challenging behaviours in an elementary school situated in a deprived neighbourhood of Istanbul, Turkey. For a period of eight months, 160 pupils received a psychosocial intervention once a week. Children’s patterns of behaviour, emotions, movements, interactivity, socialisation and interpersonal communications were observed during this period. Core activities of the intervention included library visits, reading, writing and listening games, maths games, drawing, animal animation, leaf making, ball games, parachuting games, colouring, hula-hoop and driver-car role plays. At the end of the intervention, one group of children made signifcant improvements in behavioural changes while no improvements were observed for another group. Although further research is required to generalize beyond the reference group, the fndings suggest that a robust collaboration between inter-agency community partnership and universities can play a crucial role in responding to the needs of marginalized children with psychological and emotional problems.Yayın REBT with context of basic psychological needs: RESD-A Scale(Cambridge University Press, 2020) Artiran, Murat; Simsek, Omer Faruk; Turner, MartinBackground: Accurate psychometrics benefit from assessing given constructs within specifically defined contexts. The assessment of context-specific irrational beliefs as put forth in rational emotive behaviour therapy (REBT), under the three basic psychological needs described in self-determination theory (SDT), represents a new path for research. Under the umbrella of 'positive psychology', a new scale for adolescents combining REBT and SDT is the first step towards conceptualizing irrational beliefs within the three basic psychological needs. The integration of REBT and SDT would provide a more fully integrated view of adolescent mental health, and as such could provide a more cost-effective approach for preventing cognitive, emotive and behavioural disturbances in young people. Aims: The main aim of this paper is to outline the development and validation of the Rational Emotive Self Determination Scale for Adolescents (RESD-A), which measures irrational beliefs about the three basic psychological needs (autonomy, competence and relatedness). Method: To achieve this main study aim, we report the results of four studies that test the factor structure, internal consistency, construct, predictive validity, and test-re-test reliability of the 51-item RESD-A, within samples of Turkish adolescents. Results: Data analyses confirmed the theoretical expectations and yielded promising results for the validity and reliability of the RESD-A. Conclusions: The results suggest that assessment of irrational beliefs in the context of autonomy, competence and relatedness is possible and valuable for the treatment of adolescents.Yayın Relationship between individualized care perception and innovativeness among final-year nursing students(Wiley, 2020) Demirel, Nehir; Turan, NurayPurpose The aim of this study was to evaluate the relationship between individualized care (IC) perceptions and innovativeness among final-year nursing students. Design and Methods The population of this analytical study consisted of 230 students. Data were collected using a student information form (individualized care scale [ICS]-nurse version, individual innovativeness). Data analysis was carried out using descriptive, comparative, correlational, and stepwise regression analysis statistics. Findings Nursing students had a high perception of IC and an early majority level of innovativeness. As their innovativeness levels increased, their perceptions of IC also increased. There was a positive correlation between the total ICS-A-nurse score and the individual innovativeness scale/openness to experience subscale. In regression analysis, the individual innovativeness total increased IC. Practice Implications Courses and practical work should be organized for students to raise their awareness of IC and to increase their innovativeness.Yayın Searching Evidences of Stroke in Animal Models: A Review of Discrepancies(TURKISH NEUROSURGICAL SOC, 2017) Kaya, Ahmet Hilmi; Erdogan, Hakan; Tasdemiroglu, ErolSo far, animal models have helped us better understand the pathophysiology of the ischemic brain damage but they could not contribute so much to clinical practice. The discrepancies in results regarding neuroprotective agents in animal experiments compared to clinical trials have not been solved. Various animal models of ischemic stroke have proven efficacy of many neuroprotective agents without any considerable result in phase III clinical trials. As is well known, stroke-related focal cerebral ischemia or cardiac arrest related global cerebral ischemia are major causes of disability and death among human subjects. Animal models are essential to evaluate the therapeutic approaches for humans. In this review, we will try to answer two important questions: 1) Which factors endanger the reliability of experimental studies of stroke on animal models? 2) How can we design our experiments to reflect the neurorestoration and/or neuroprotection mechanisms following ischemic injury, when it comes to human disease?Yayın Effects of escitalopram on ethanol withdrawal syndrome in rats(PERGAMON-ELSEVIER SCIENCE LTD, 2006) Saglam, Esra; Kayir, Hakan; Celik, Turgay; Uzbay, TayfunThe present study was designed to investigate the effects of escitalopram, a selective serotonin reuptake inhibitor, on ethanol withdrawal syndrome in rats. Adult male Wistar rats (266-278 g) were subjects. Ethanol (7.2%, v/v) was given to rats by a liquid diet for 21 days. Control rats were pair fed with an isocaloric liquid diet containing sucrose as a caloric substitute to ethanol. Escitalopram, (2.5, 5 and 10 mg/kg) and saline were injected to rats intraperitoneally just before ethanol withdrawal. After the second and sixth hours of ethanol withdrawal, rats were observed for 5 min, and withdrawal signs that included locomotor hyperactivity, agitation, stereotyped behavior, wet dog shakes, tremors and audiogenic seizures were recorded or rated. A second series of injections was given 30 min before sixth hour of withdrawal test. Effects of escitalopram on the locomotor activities of the naive (no ethanol-dependent) rats were also evaluated. Escitalopram (5 mg/kg) reduced the increased stereotyped behaviors at the sixth hour of ethanol withdrawal. It inhibited tremors at the second hour of ethanol withdrawal at doses of 5 and 10 mg/kg. Escitalopram (2.5 and 5 mg/kg) also produced some significant attenuations in the incidence of wet dog shakes at the second and sixth hours of the observation period. It was found ineffective on locomotor hyperactivity, agitation and audiogenic seizures. Escitalopram (2.5 and 5 mg/kg) did not cause any significant effect on locomotor activities of the naive rats. Our results suggest that acute escitalopram treatment has some limited beneficial effects on ethanol withdrawal syndrome in rats. (c) 2006 Elsevier Inc. All rights reserved.Yayın Hippocampus and amygdalar volumes in patients with refractory obsessive-compulsive disorder(PERGAMON-ELSEVIER SCIENCE LTD, 2008) Atmaca, Murad; Yildirim, Hanefi; Ozdemir, Huseyin; Ozler, Sinan; Kara, Bilge; Ozler, Zuhal; Kanmaz, Ebru; Mermi, Osman; Tezcan, ErtanFunctional and structural neuroimaging studies have implicated the hippocampus-amygdala complex in the pathophysiology of obsessive-compulsive disorder (OCD), although no consensus has been established. These brain regions have not been investigated in refractory OCD patients. Volumes of the hippocampus, and amygdala were measured by magnetic resonance imaging (MRI) in a sample of 14 refractory OCD patients and 14 healthy comparison subjects. The mean left and right hippocampal and amygdala volumes of the patients were smaller than those of the healthy controls. OCD severity was not correlated with amygdala volumes but was related to the left hippocampus. Duration of illness was correlated with both hippocampus and left amygdala. Our findings suggest that hippocampus and amygdalar abnormalities can be considered in refractoriness to OCD. (C) 2008 Elsevier Inc. All rights reserved.Yayın Percutaneous endoscopic gastrostomy: A safe and effective bridge for enternal nutrition in neurological or non-neurological conditions(2004) Gencosmanoglu R.Percutaneous endoscopic gastrostomy (PEG) is one of the most commonly used methods for nutritional support in patients who are unable to take food orally. Traditional surgical gastrostomy, percutaneous radiologic gastrostomy, and laparoscopic gastrostomy are the alternatives. The most common indication is neurogenic dysphagia followed by obstructive causes such as head and neck tumors. Ethically justified and clinically comprehensive guidelines should be followed during the decision-making process for PEG tube placement. A limited life expectancy; technical difficulties, such as the inability to bring the anterior gastric wall in apposition to the abdominal wall; or pharyngeal/esophageal obstruction, which compromise tube insertion, peritonitis, and uncorrectable coagulopathy are absolute contraindications. The "pull method" is the first described and still the most performed technique of PEG tube placement. The procedure is simple, safe, and effective and fulfills all requirements to provide an ideal route for nutritional support. This article summarizes the reported experience on PEG in the current literature and discusses its utility in patients with neurological conditions. Copyright © 2004 Humana Press Inc. All rights of any nature whatsoever are reserved.Yayın Morphologic structures and identification of dark (Dematiaceous) fungi [Esmer (Dematiaceous) mantarlarin morfolojik yapilari ve tanimlanmalari](2004) Özyaral O.Dematiaceous fungi are dark brown, olivaceous or black pigmented groups of fungi. As only and shared characteristic, they belong to the class of Deuteromycetes, order Moniliales, genus Hyphomycetes, and they produce melanin or dihydroxinaphtalene-melanin. Their identification is mainly based on their morphological structure. In this review article, some microscopic properties and differentiation criteria have been discussed for the morphological identification of these fungi.Yayın Erector spinae plane block: a systematic qualitative review(EDIZIONI MINERVA MEDICA, 2019) De Cassai, Alessandro; Bonvicini, Daniele; Correale, Christelle; Sandei, Ludovica; Tulgar, Serkan; Tonetti, TommasoINTRODUCTION: The erector spinae plane (ESP) block is an interfascial block proposed to provide analgesia for chronic thoracic pain. It consists in an injection of local anesthetic in a plane between the transverse process and the erector spinae muscles group. EVIDENCE ACQUISITION: We performed a systematic review of literature following the PRISMA Statement Guidelines. The bibliographic search was conducted on September 2018. We included articles indexed in MEDLINE, EMBASE, Cochrane Library and Google Scholar. Search terms included the following: "erector spinae plane block" OR "ESP block" OR "erector spinae block." We identified 367 studies and after removal of 206 duplicates and exclusion of 18 records we manually searched 140 studies. EVIDENCE SYNTHESIS: We identified four randomized controlled trials, but the endpoints were heterogeneous preventing a statistical analysis; we performed then a qualitative review of the literature. Studies showed lower use of opioids and a longer time to first analgesic requirement in the ESP group. In one study, ESP block was found to be as effective as epidural analgesia. ESP block has a wide range of clinical indications. Its mechanism of action is still not thoroughly understood. Only two reports presented complications caused by the block. CONCLUSIONS: Although data suggests that ESP block is an easy and safe technique, more studies are needed to assess safety, complications rates and efficacy of this technique. In particular, we need well designed RCTs comparing ESP block to gold standard regional anesthesia technique. Nevertheless, ESP block is already a viable option for anesthesiologists all over the world.Yayın Exercise and melatonin in humans: reciprocal benefits(WILEY-BLACKWELL, 2012) Escames, Germaine; Ozturk, Guler; Bano-Otalora, Beatriz; Pozo, Maria J.; Madrid, Juan A.; Reiter, Russel J.; Serrano, Eric; Concepcion, Melquiades; Acuna-Castroviejo, DarioThe aim of this review is to update the reader as to the association between physical exercise and melatonin, and to clarify how the melatonin rhythm may be affected by different types of exercise. Exercise may act as a zeitgeber, although the effects of exercise on the human circadian system are only now being explored. Depending on the time of the day, on the intensity of light, and on the proximity of the exercise to the onset or decline of the circadian production of melatonin, the consequence of exercise on the melatonin rhythm varies. Moreover, especially strenuous exercise per se induces an increased oxidative stress that in turn may affect melatonin levels in the peripheral circulation because indole is rapidly used to combat free radical damage. On the other hand, melatonin also may influence physical performance, and thus, there are mutually interactions between exercise and melatonin production which may be beneficial.Yayın Breast Metastases in Children and Adolescents With Rhabdomyosarcoma: A Large Single-Institution Experience and Literature Review(LIPPINCOTT WILLIAMS & WILKINS, 2017) Kebudi, Rejin; Koc, Begum S.; Gorgun, Omer; Celik, Alaaddin; Kebudi, Abut; Darendeliler, EminIntroduction: Breast metastasis is rare in childhood malignancies. Soft tissue sarcomas, especially rhabdomyosarcomas (RMS), and hematologic neoplasms, such as lymphomas, are the most common tumors that metastasize to the breast, albeit rare. Materials and Methods: All cases with breast metastasis within a cohort of 200 RMS patients followed in our institution during 1990 to 2014 were assessed retrospectively and the literature was reviewed. Results: There were 3 adolescent female patients with breast metastasis. All had alveolar histology. The primary tumors were in the parameningeal sites, extremities, and the perineum, respectively. Two patients had breast metastasis at diagnosis, and 1 during follow-up. In 1 breast lesion, there was a complete response to chemotherapy, and in another there was no response to chemotherapy, and the patient underwent radical mastectomy. In the third patient, there was partial response, and lesions progressed. All patients died with recurrent/progressive disease, 2 with no recurrence in the breast. In the English literature, there are 70 cases including our cases. All but 1 involve female patients, all adolescents, most have alveolar histology and poor prognosis. All had chemotherapy, whereas some had surgery and/or radiotherapy for local treatment. Conclusion: Breast metastasis should be considered in adolescent female patients with RMS. Optimal management is not clear. Besides chemotherapy, mastectomy and radiotherapy should be considered on a case basis.Yayın Cervical bronchogenic cysts in head and neck region: review of the literature(CAMBRIDGE UNIV PRESS, 2005) Ustundag, E; Iseri, M; Keskin, G; Yayla, B; Muezzinoglu, BCongenital cysts of the neck are not uncommon. Most of these are thyroglossal, branchial cleft and thymic cysts. Bronchogenic cysts are uncommon developmental anomalies of the tracheobronchial tree and rarely occur in the neck. More than 70 cases of bronchogenic cysts in the head and neck region have been reported in the literature. We report three cases presenting with neck swelling in the hyoid region that were diagnosed as bronchogenic cysts based on clinical and histopathological findings.Yayın Sonography of fat necrosis of the breast: Correlation with mammography and MR imaging(WILEY, 2013) Atasoy, Mehmet Mahir; Oren, Nisa Cem; Ilica, Ahmet Turan; Guvenc, Inanc; Gunal, Armagan; Mossa-Basha, MahmudFat necrosis (FN) of the breast is a benign nonsuppurative inflammatory process of the adipose tissue. The radiologic appearance ranges from benign to suspicious for malignancy; therefore, it is very important to know the distinguishing radiologic features of FN on different modalities. Mammography is more helpful in identifying FN than ultrasonography in most of the cases, and MRI may also be used to rule out malignancy as an adjunct to mammography and sonography. Even when modern diagnostic modalities are used, biopsy may still be unavoidable for some cases. In conclusion, an accurate history and familiarity with the radiologic findings are crucial to recognizing FN and avoiding unnecessary interventions. (c) 2013 Wiley Periodicals, Inc. J Clin Ultrasound41:415-423, 2013Yayın Anticancer Use of Nanoparticles as Nucleic Acid Carriers(AMER SCIENTIFIC PUBLISHERS, 2014) Gozuacik, D.; Yagci-Acar, H. F.; Akkoc, Y.; Kosar, A.; Dogan-Ekici, A. Isin; Ekici, SinanAdvances in nanotechnology opened up new horizons in the field of cancer research. Nanoparticles made of various organic and inorganic materials and with different optical, magnetic and physical characteristics have the potential to revolutionize the way we diagnose, treat and follow-up cancers. Importantly, designs that might allow tumor-specific targeting and lesser side effects may be produced. Nanoparticles may be tailored to carry conventional chemotherapeutics or new generation organic drugs. Currently, most of the drugs that are commonly used, are small chemical molecules targeting disease-related enzymes. Recent progress in RNA interference technologies showed that, even proteins that are considered to be "undruggable" by small chemical molecules, might be targeted by small RNAs for the purpose of curing diseases, including cancer. In fact, small RNAs such as siRNAs, shRNAs and miRNAs can drastically change cellular levels of almost any given disease-associated protein or protein group, resulting in a therapeutic effect. Gene therapy attempts were failing mainly due to delivery viral vector-related side effects. Biocompatible, non-toxic and efficient nanoparticle carriers raise new hopes for the gene therapy of cancer. In this review article, we discuss new advances in nucleic acid and especially RNA carrier nanoparticles, and summarize recent progress about their use in cancer therapy.Yayın Prenatal diagnosis of Comel-Netherton syndrome with PGD, case report and review article(SPRINGER/PLENUM PUBLISHERS, 2011) Bingol, Banu; Tasdemir, Seval; Gunenc, Ziya; Abike, Faruk; Esenkaya, Semra; Tavukcuoglu, Safak; Berkil, Hakan…Yayın Spontaneous rupture of a coronary artery aneurysm - A case report and review of the literature(JAPAN HEART JOURNAL, SECOND DEPT OF INTERNAL MED, 2004) Gunduz, H; Akdemir, R; Binak, E; Tamer, A; Uyan, CCoronary artery aneurysm (CAA) is. a rare disorder, characterized by abnormal dilatation of a localized portion or diffuse segments of the coronary artery. CAA may cause angina, myocardial infarction, sudden death due to thrombosis, embolisation, or rupture. In this report, a 63 year old Turkish male patient is presented who had an acute non-Q wave myocardial infarction due to spontaneous rupture of the left circumflex artery aneurysm. An extremely rare clinical presentation of rupture of a left circumflex CAA is discussed.Yayın A case of epibulbar osseous choristoma with review of literature(SPRINGER, 2014) Balci, Ozlem; Oduncu, AbdulkadirEpibulbar osseous choristomas are rare congenital simple choristomas consisting of pure bone on the sclera. It is usually recognized in childhood and most often located in the superotemporal quadrant. A case of 7-year-old male who presented with a history of mass in the left eye was reported in this paper. The mass had been present since birth but had showed slight enlargement during the last 6 months. Examination revealed a 7 x 5 mm reddish, hard, and mobile mass located in the superotemporal quadrant. Excisional biopsy was done. On histopathological examination, excised mass was found to be composed of mature bony trabeculae enclosing osteocytes, and diagnosis of epibulbar osseous choristoma was made.Yayın Preeclampsia Due to Fetal Non-immune Hydrops: Mirror Syndrome and Review of Literature(INFORMA HEALTHCARE, 2011) Gedikbasi, Ali; Oztarhan, Kazim; Gunenc, Ziya; Yildirim, Gokhan; Arslan, Oguz; Yildirim, Dogukan; Ceylan, YavuzObjective. Mirror syndrome (Ballantyne's syndrome) refers to the association of fetal hydrops and maternal preeclampsia. The aim of this study was to determine the relation and incidence between fetal hydrops and preeclampsia in our clinic. Methods. A retrospective review of patients associated with fetal hydrops and findings with preeclampsia was used. Seventy-five cases with single pregnancy and diagnoses with nonimmune hydrops fetalis were found. According to the data 4 cases were found related with preeclampsia. Results. Mirror syndrome is rarely encountered and underdiagnosed. We found a frequency of 5.3% (4 cases in 75 affected pregnancies) for single non-immune hydrops cases in which maternal hypertension occurred. Fetal outcome is depending on etiology and prognosis is mainly very low. Maternal symptoms and laboratory findings are resolving after intrauterine fetal death or delivery. Conclusion. Hydrops fetalis must be considered as a potential risk factor for preeclampsia. It is important that this clinical condition has a potential of about 5% for proceeding preeclampsia.
