Amantadine might be used as a drug for SARS-Cov-2 treatment?

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dc.authorid0000-0002-3060-1507en_US
dc.authorid0000-0003-2016-9965en_US
dc.contributor.authorÖzünal, Zeynep Güneş
dc.contributor.authorŞahin, Şevki
dc.date.accessioned2024-07-12T21:03:06Z
dc.date.available2024-07-12T21:03:06Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractCoronavirus Disease 2019 (COVID-19) infection, the pandemics, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has no known effective radical pharmacotherapy and just supportive approach at present. Amantadine is a drug used in Parkinson’s disease and other parkinsonisms; and is known to increase indirectly dopamine by antagonistic effects at the N-methyl-Daspartate (NMDA) receptor by increasing the release and blocking the reuptake of dopamine. Initially, amantadine was approved as an antiviral drug. We hypothesize that if amantadine is considered its antiviral, immunological and neurostimulant effects might be useful in the supportive treatment of SARSCoV-2 cases, especially those who developed acute respiratory failure with decreased vigilance and are being monitored in the intensive care unit. Further phase III clinical trials are needed.en_US
dc.identifier.citationÖzünal, Z. G. ve Şahin, Ş. (2021). Amantadine might be used as a drug for SARS-Cov-2 treatment. Coronaviruses, Bentham Science. 2, s. 6-7.en_US
dc.identifier.doi10.2174/2666796701999200713192912
dc.identifier.endpage7en_US
dc.identifier.scopus2-s2.0-85148353431en_US
dc.identifier.startpage6en_US
dc.identifier.urihttps://www.eurekaselect.com/183729/article
dc.identifier.urihttps://doi.prg/10.2174/2666796701999200713192912
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3631
dc.identifier.volume2en_US
dc.indekslendigikaynakScopus
dc.institutionauthorÖzünal, Zeynep Güneş
dc.language.isoenen_US
dc.publisherBentham Scienceen_US
dc.relation.ispartofCoronavirusesen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.snmzKY00566
dc.subjectAmantadineen_US
dc.subjectPharmacologyen_US
dc.subjectNeurologyen_US
dc.subjectSARS-CoV-2en_US
dc.subjectDrug repositioningen_US
dc.subjectCOVID-19en_US
dc.titleAmantadine might be used as a drug for SARS-Cov-2 treatment?en_US
dc.typeArticle
dspace.entity.typePublication

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