Amantadine might be used as a drug for SARS-Cov-2 treatment?
Küçük Resim Yok
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bentham Science
Erişim Hakkı
Attribution-NonCommercial-NoDerivs 3.0 United States
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Coronavirus Disease 2019 (COVID-19) infection, the pandemics, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has no known effective radical pharmacotherapy and just supportive approach at present. Amantadine is a drug used in Parkinson’s disease and other parkinsonisms; and is known to increase indirectly dopamine by antagonistic effects at the N-methyl-Daspartate (NMDA) receptor by increasing the release and blocking the reuptake of dopamine. Initially, amantadine was approved as an antiviral drug. We hypothesize that if amantadine is considered its antiviral, immunological and neurostimulant effects might be useful in the supportive treatment of SARSCoV-2 cases, especially those who developed acute respiratory failure with decreased vigilance and are being monitored in the intensive care unit. Further phase III clinical trials are needed.
Açıklama
Anahtar Kelimeler
Amantadine, Pharmacology, Neurology, SARS-CoV-2, Drug repositioning, COVID-19
Kaynak
Coronaviruses
WoS Q Değeri
Scopus Q Değeri
Cilt
2
Sayı
Künye
Özünal, Z. G. ve Şahin, Ş. (2021). Amantadine might be used as a drug for SARS-Cov-2 treatment. Coronaviruses, Bentham Science. 2, s. 6-7.
