Prevalance and prognostic value of c-erbB2 expression in non-small cell lung cancer (NSCLC)

Basit Öğe Kaydı
dc.authorid0000-0002-4075-6692en_US
dc.contributor.authorKunter, E.
dc.contributor.authorÇermik, H.
dc.contributor.authorIşıtmangil, T.
dc.contributor.authorKandemir, E. G.
dc.contributor.authorYaylacı, Mustafa
dc.contributor.authorÖztürk, A.
dc.date.accessioned2024-07-12T21:10:22Z
dc.date.available2024-07-12T21:10:22Z
dc.date.issued2003en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractThe c-erbB2 oncoprotein is highly expressed in approximately one third of non-small cell lung cancer (NSCLC) patients. We determined the status of c-erbB2 expression in our patients with NSCLC and investigated its correlation with disease stage, histological type and response to treatment. Eighty-four patients were examined for the expression of c-erbB2 by immunohistochemistry using a polyclonal antibody. The scoring criteria of Clinical Trial Assay (CTA) were used to evaluate staining (0 to +3). c-erbB2 overexpression was determined in 35% of the cases. Tumors from higher stage disease (stage IIIb-IV) were more often c-erbB2 positive in adenocarcinoma (ADC) (p=0.04). In addition, there was an association between c-erbB2 score and disease stage in ADC patients (p=0.03). Our study did not demonstrate an association of c-erbB2 overexpression with response to chemotherapy. We conclude that c-erbB2 overexpression may be a prognostic marker for evaluating tumor progression in NSCLC patients but further studies must be performed with larger patient populations.en_US
dc.identifier.citationTürken O, Kunter E, Çermik H, Işıtmangil T, Kandemir EG, Yaylacı M, Öztürk A. Prevalance and prognostic value of c-erbB2 expression in non-small cell lung cancer (NSCLC). Neoplasma, AEPress. 50, s. 257-261.en_US
dc.identifier.endpage261en_US
dc.identifier.issn0028-2685
dc.identifier.issn1338-4317
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage257en_US
dc.identifier.urihttp://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=675&category_id=31&option=com_virtuemart&vmcchk=1&Itemid=1
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4242
dc.identifier.volume50en_US
dc.institutionauthorTürken, Orhan
dc.language.isoenen_US
dc.publisherAEPressen_US
dc.relation.ispartofNeoplasmaen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY03086
dc.subjectNon-smallen_US
dc.subjectlungen_US
dc.subjectcanceren_US
dc.subjectc-erbB2en_US
dc.titlePrevalance and prognostic value of c-erbB2 expression in non-small cell lung cancer (NSCLC)en_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

Tıp Fakültesi Koleksiyonu