Prevalance and prognostic value of c-erbB2 expression in non-small cell lung cancer (NSCLC)
Küçük Resim Yok
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
AEPress
Erişim Hakkı
CC0 1.0 Universal
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
The c-erbB2 oncoprotein is highly expressed in approximately one third of non-small cell lung cancer (NSCLC) patients. We determined the status of c-erbB2 expression in our patients with NSCLC and investigated its correlation with disease stage, histological type and response to treatment. Eighty-four patients were examined for the expression of c-erbB2 by immunohistochemistry using a polyclonal antibody. The scoring criteria of Clinical Trial Assay (CTA) were used to evaluate staining (0 to +3). c-erbB2 overexpression was determined in 35% of the cases. Tumors from higher stage disease (stage IIIb-IV) were more often c-erbB2 positive in adenocarcinoma (ADC) (p=0.04). In addition, there was an association between c-erbB2 score and disease stage in ADC patients (p=0.03). Our study did not demonstrate an association of c-erbB2 overexpression with response to chemotherapy. We conclude that c-erbB2 overexpression may be a prognostic marker for evaluating tumor progression in NSCLC patients but further studies must be performed with larger patient populations.
Açıklama
Anahtar Kelimeler
Non-small, lung, cancer, c-erbB2
Kaynak
Neoplasma
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
50
Sayı
Künye
Türken O, Kunter E, Çermik H, Işıtmangil T, Kandemir EG, Yaylacı M, Öztürk A. Prevalance and prognostic value of c-erbB2 expression in non-small cell lung cancer (NSCLC). Neoplasma, AEPress. 50, s. 257-261.
