The severity of inflammation in major neuropsychiatric disorders: comparison of neutrophil–lymphocyte and platelet–lymphocyte ratios between schizophrenia, bipolar mania, bipolar depression, major depressive disorder, and obsessive compulsive disorder

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dc.authorid0000-0002-0582-4936en_US
dc.contributor.authorBulut, Necati Serkut
dc.contributor.authorYorguner, Neşe
dc.contributor.authorBulut, Gresa Çarkaxhiu
dc.date.accessioned2024-07-12T21:10:26Z
dc.date.available2024-07-12T21:10:26Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBackground: As non-specific markers of immune dysregulation, neutrophil–lymphocyte and platelet– lymphocyte ratios (NLR and PLR) have been consistently shown to be increased in major neuropsychiatric disorders. Although this increase seems to be trans-diagnostic, the extent to which its magnitude differs between disorders remains largely unclear. Aim: The aim of this study was to directly compare the severity of inflammation (as reflected by NLR and PLR) between schizophrenia (Sch), bipolar mania (BD-M), bipolar depression (BD-D), major depressive disorder (MDD) and obsessive compulsive disorder (OCD). Methods: NLR and PLR were obtained for a total of 417 subjects (91 Sch, 70 BD-D, 37 BD-M, 93 MDD, 37 OCD, and 95 controls) and analyzed for group differences. Results: Sch, BD-M, BD-D and MDD presented with significantly higher NLR compared with both OCD and HC. NLR in BD-M was significantly higher than all the remaining groups, whereas Sch, BD-D and MDD presented with comparably elevated NLR. Moreover, BD-M, Sch and MDD had significantly higher PLR compared with HC. Conclusion: These results suggest that the underlying inflammation may be most severe in BD-M, followed by Sch, BD-D and MDD. On the other hand, inflammation may be of negligible intensity in OCD, or at least undetectable by means of NLR or PLR.en_US
dc.identifier.citationBulut, N.S., Yorguner, N. and Bulut, G.Ç. (2021). The severity of inflammation in major neuropsychiatric disorders: comparison of neutrophil–lymphocyte and platelet–lymphocyteratios between schizophrenia, bipolar mania,bipolar depression, major depressive disorder, and obsessive compulsive disorder. Nordic Journal of Psychiatry, 75(8), p.624-632.en_US
dc.identifier.doi10.1080/08039488.2021.1919201
dc.identifier.endpage632en_US
dc.identifier.issue8en_US
dc.identifier.pmid34319861en_US
dc.identifier.scopus2-s2.0-85111672051en_US
dc.identifier.startpage624en_US
dc.identifier.urihttps://doi.prg/10.1080/08039488.2021.1919201
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4251
dc.identifier.volume75en_US
dc.identifier.wosWOS:000678627200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBulut, Gresa Çarkaxhiu
dc.language.isoenen_US
dc.publisherNordic Journal of Psychiatryen_US
dc.relation.ispartofNordic Journal of Psychiatryen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03136
dc.subjectInflammationen_US
dc.subjectSchizophreniaen_US
dc.subjectBipolar disorderen_US
dc.subjectMajor depressive disorderen_US
dc.subjectObsessive compulsive disorderen_US
dc.titleThe severity of inflammation in major neuropsychiatric disorders: comparison of neutrophil–lymphocyte and platelet–lymphocyte ratios between schizophrenia, bipolar mania, bipolar depression, major depressive disorder, and obsessive compulsive disorderen_US
dc.typeArticle
dspace.entity.typePublication

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