Subcellular distribution of basic fibroblast growth factor-like molecules ın fibroblasts and extracellular matrix

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dc.authorid0000-0002-4474-7371en_US
dc.contributor.authorKayton, Robert J.
dc.date.accessioned2024-07-12T21:10:12Z
dc.date.available2024-07-12T21:10:12Z
dc.date.issued1999en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBasic fibroblast growth factor (bFGF) is thought to play an important role in normal tissue repair and wound healing. It is a potent mitogenic and chemotactic factor for fibroblasts. To some degree bFGF regulates proliferation and extracellular matrix (ECM) production by these cells. In this study we investigate (i) the distribution of bFGF in fibroblasts and ECM of supporting tissues (ii) the subcellular location of this protein in vivo and, (iii) mechanisms for release of this growth factor from fibroblasts. Spurr's resin embedded ultrathin sections from adult rat sciatic nerve, adrenal gland, kidney; and from normal human lung and skin were labeled with either polyclonal (F3393-Sigma) or monoclonal antibodies (F6162-Sigma, C3316-ZymoGenetics Inc.) specific for bFGF using a two-step immunogold labeling method. Controls were incubated with either an equivalent volume of blocking solution (omitting the primary antibody) or an irrelevant antibody (Factor VIII, anti-Histamine)(Fig. 4).en_US
dc.identifier.citationAktas, R. G. and Kayton, R. J. (1999). Subcellular Distribution Of Basic Fibroblast Growth Factor-Like Molecules In Fibroblasts And Extracellular Matrix. Microscopy and Microanalysis, Cambridge University Press. 5(S2), s. 1332–1333.en_US
dc.identifier.endpage1333en_US
dc.identifier.issn1435-8115
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1332en_US
dc.identifier.urihttps://www.cambridge.org/core/journals/microscopy-and-microanalysis/article/subcellular-distribution-of-basic-fibroblast-growth-factorlike-molecules-in-fibroblasts-and-extracellular-matrix/5ADC5A86F8DA39F36D8AD1A86DD75B62
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4212
dc.identifier.volume5en_US
dc.institutionauthorAktas, Ranan Gulhan
dc.language.isoenen_US
dc.publisherCambridge University Pressen_US
dc.relation.ispartofMicroscopy and Microanalysisen_US
dc.relation.isversionof10.1017/S143192760001998Xen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY02937
dc.titleSubcellular distribution of basic fibroblast growth factor-like molecules ın fibroblasts and extracellular matrixen_US
dc.typeArticle
dspace.entity.typePublication

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