Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats

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dc.authorid0000-0002-6197-7654en_US
dc.contributor.authorOrak, Mehmet Mufit
dc.contributor.authorAk, Dursun
dc.contributor.authorMidi, Ahmet
dc.contributor.authorLacin, Berna
dc.contributor.authorPurisa, Sevim
dc.contributor.authorBulut, Guven
dc.date.accessioned2024-07-12T21:44:20Z
dc.date.available2024-07-12T21:44:20Z
dc.date.issued2015en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjective: Lyophilized drug manufacturing and intra-articular (IA) applications have increased to address gastrointestinal side effects resulting from chronic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) for degenerative joint disease. Accordingly, we histologically examined joint and stomach tissues from rats to determine and compare the effects of long-term treatment with an IA corticosteroid (methylprednisolone acetate), lyophilized NSAID (tenoxicam), and non-lyophilized NSAID (diclofenac) following application to the knee joint. Methods: One hundred Wistar albino rats were divided into 4 groups of 25 rats: control, methylprednisolone, tenoxicam, and diclofenac. Ten IA injections were administered at 1-week intervals. Rats were sacrificed at 48 h and 1, 2, 4, and 8 weeks after the tenth injection. Histomorphologically, knee joint samples were examined for osteoarthritic changes and stomach tissue samples for gastric changes. Results: Unlike methylprednisolone, diclofenac and tenoxicam caused increased fibrosis and fibroblast production; furthermore, chronic methylprednisolone use had no negative effects on the synovium or cartilage. Conclusion: Chronic tenoxicam and diclofenac use affects joints more negatively than chronic steroid treatment.en_US
dc.identifier.doi10.3944/AOTT.2015.14.0312
dc.identifier.endpage446en_US
dc.identifier.issn1017-995X
dc.identifier.issue4en_US
dc.identifier.pmid26312474en_US
dc.identifier.scopus2-s2.0-84944679584en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage438en_US
dc.identifier.urihttps://dx.doi.org/10.3944/AOTT.2015.14.0312
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7715
dc.identifier.volume49en_US
dc.identifier.wosWOS:000360920200017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTURKISH ASSOC ORTHOPAEDICS TRAUMATOLOGYen_US
dc.relation.ispartofACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00058
dc.subjectDiclofenacen_US
dc.subjectexperimental studyen_US
dc.subjectintraarticularen_US
dc.subjectmethylprednisoloneen_US
dc.subjecttenoxicamen_US
dc.titleComparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy ratsen_US
dc.typeArticle
dspace.entity.typePublication

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