Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TURKISH ASSOC ORTHOPAEDICS TRAUMATOLOGY
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Lyophilized drug manufacturing and intra-articular (IA) applications have increased to address gastrointestinal side effects resulting from chronic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) for degenerative joint disease. Accordingly, we histologically examined joint and stomach tissues from rats to determine and compare the effects of long-term treatment with an IA corticosteroid (methylprednisolone acetate), lyophilized NSAID (tenoxicam), and non-lyophilized NSAID (diclofenac) following application to the knee joint. Methods: One hundred Wistar albino rats were divided into 4 groups of 25 rats: control, methylprednisolone, tenoxicam, and diclofenac. Ten IA injections were administered at 1-week intervals. Rats were sacrificed at 48 h and 1, 2, 4, and 8 weeks after the tenth injection. Histomorphologically, knee joint samples were examined for osteoarthritic changes and stomach tissue samples for gastric changes. Results: Unlike methylprednisolone, diclofenac and tenoxicam caused increased fibrosis and fibroblast production; furthermore, chronic methylprednisolone use had no negative effects on the synovium or cartilage. Conclusion: Chronic tenoxicam and diclofenac use affects joints more negatively than chronic steroid treatment.
Açıklama
Anahtar Kelimeler
Diclofenac, experimental study, intraarticular, methylprednisolone, tenoxicam
Kaynak
ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
49
Sayı
4
