Accidental oral poisoning caused by RDX (cyclonite): a report of 5 cases

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dc.authorid0000-0003-4170-7865en_US
dc.authorid0000-0002-0603-3896en_US
dc.authorid0000-0003-2617-0609en_US
dc.contributor.authorKüçükardalı, Yaşar
dc.contributor.authorAcar, H. Volkan
dc.contributor.authorÖzkan, Sezai
dc.contributor.authorNalbant, Selim
dc.contributor.authorYazgan, Yusuf
dc.contributor.authorAtasoyu, Enes Murat
dc.contributor.authorKeskin, Özcan
dc.contributor.authorNaz, Alişan
dc.contributor.authorAkyatan, Nevzat
dc.contributor.authorGökben, Melih
dc.contributor.authorDanacı, Mehmet
dc.date.accessioned2024-07-12T21:04:41Z
dc.date.available2024-07-12T21:04:41Z
dc.date.issued2003en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractThe explosive RDX (hexogen, cyclonite) is usually used for the production of C-4 explosive. The rare occurrence of accidental and intentional RDX intoxications has been reported during manufacturing process or in wartime. In this article, the authors report 5 cases of accidental oral RDX poisoning. On admission, observed signs and symptoms included repetitive generalized tonic-clonic convulsions, postictal coma, lethargy, confusion, hyperreflexia, postictal amnesia, nausea, vomiting, abdominal tenderness, sinusal tachycardia, dysrhythmia with frequent ventricular premature beats, generalized muscle spasms, and myoclonus. Leukocytosis, mild anemia, methemoglobinemia, elevated levels of blood glucose, serum aspartate transaminase, alanine transaminase, lactic dehydrogenase, creatine phosphokinase, amilase, hypokalemia, metabolic acidosis, proteinuria, glucosuria, and myoglobinuria were also noted. Plasma RDX concentrations were 268 to 969 ng/mL at 3 hours of ingestion. For management, supportive and symptomatic measures were taken. Whole-bowel irrigation might have been an effective therapeutic procedure due to probable slow gastrointestinal absorption of RDX. Three patients who developed severe metabolic acidosis underwent urgent hemodialysis. All patients were discharged 7 to 21 days after admission without any sequelae. Plasma RDX levels were strongly correlated with the clinical and laboratory manifestations. The available toxicological data on this rare accidental poisoning are reviewed in light of the literature.en_US
dc.identifier.citationKüçükardalı, Y., Acar, H. V., Özkan, S., Nalbant, S., Yazgan, Y., Atasoyu, E. M., Keskin, O., Naz, A., Akyatan, N., Gökben, M. ve Danaci, M. (2003). Accidental oral poisoning caused by RDX (cyclonite): a report of 5 cases. Journal of Intensive Care Medicine, SageJournals. 18(1), s. 42-46.en_US
dc.identifier.endpage46en_US
dc.identifier.issn1525-1489
dc.identifier.issn0885-0666
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage42en_US
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/0885066602239123
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3817
dc.identifier.volume18en_US
dc.language.isoenen_US
dc.publisherSageJournalsen_US
dc.relation.ispartofJournal of Intensive Care Medicineen_US
dc.relation.isversionof10.1177/0885066602239123en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY01928
dc.titleAccidental oral poisoning caused by RDX (cyclonite): a report of 5 casesen_US
dc.typeArticle
dspace.entity.typePublication

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