Ultrastructural distribution of basic fibroblast growth factor-like molecules in peripheral nerves

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dc.authorid0000-0002-4474-7371en_US
dc.contributor.authorKayton, Robert J.
dc.date.accessioned2024-07-12T21:10:11Z
dc.date.available2024-07-12T21:10:11Z
dc.date.issued1998en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBasic Fibroblast Growth Factor (bFGF) is a multifunctional polypeptide which has been shown to play a pivotal role in the survival and differentiation of nerve cells. Several trophic and non-trophic functions of this protein have been suggested in peripheral nerves. In spite of ample information about the distribution and effects of bFGF in central nervous system, few data are available concerning the localization of this protein in peripheral nerves. In view of the role of bFGF in regulation of trophic and non-trophic functions, we particularly focused on the presence and precise location of bFGF in peripheral nerves at the electron microscope level. Spurr's resin embedded ultrathin sections from adult rats’ sural nerves were labeled with either polyclonal (F3393-Sigma) or monoclonal antibodies (F6162-Sigma, C3316-Zymogenetics) specific for bFGF using two-step immunogold labeling method. Control samples were treated with either an equivalent volume of blocking solution (omitting the primary antibody) or an irrelevant antibody (Factor VIII, VGF, anti-histamine, anti-fibroblast 5B5).en_US
dc.identifier.citationKayton, R. J. and Aktas, R. G. (1998). Ultrastructural Distribution of Basic Fibroblast Growth Factor-Like Molecules in Peripheral Nerves. Microscopy and Microanalysis, 4(S2), s. 1102–1103.en_US
dc.identifier.endpage1103en_US
dc.identifier.issn1435-8115
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1102en_US
dc.identifier.urihttps://www.cambridge.org/core/journals/microscopy-and-microanalysis/article/ultrastructural-distribution-of-basic-fibroblast-growth-factorlike-molecules-in-peripheral-nerves/20C97CA7FD414260D116ED548F65C8DA
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4208
dc.identifier.volume4en_US
dc.institutionauthorAktas, Ranan Gulhan
dc.language.isoenen_US
dc.publisherCambridge University Pressen_US
dc.relation.ispartofMicroscopy and Microanalysisen_US
dc.relation.isversionof10.1017/S1431927600025630en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY02933
dc.titleUltrastructural distribution of basic fibroblast growth factor-like molecules in peripheral nervesen_US
dc.typeArticle
dspace.entity.typePublication

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