Third trimester nonrecurrent fetal loss is associated with factor V Leiden and prothrombin gene mutations

Basit Öğe Kaydı
dc.authorid0000-0002-3166-9052en_US
dc.contributor.authorKarateke, Ateş
dc.contributor.authorHaliloğlu, Berna
dc.contributor.authorGürbüz, Ayşe
dc.date.accessioned2024-07-12T21:05:01Z
dc.date.available2024-07-12T21:05:01Z
dc.date.issued2005en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObjective: To determine the role of factor V Leiden and prothrombin gene mutation in the pathogenesis of unexplained second and third trimester nonrecurrent fetal loss. Materials and methods: One hundred and fourteen women with unexplained nonrecurrent late fetal loss made up the study group, and 106 normal pregnant women with a history of delivery of at least one healthy fetus and no history of late fetal loss made up the control group. The study group was further divided into two subgroups: second (n = 36) and third (n = 78) trimester fetal loss. All women were tested for factor V Leiden and G20210A prothrombin gene mutations. Results: Twenty-one (18.4%) of the women in the study group and seven (6.6%) of the women in the control group were heterozygous carriers of factor V Leiden mutation (OR = 3.19). Eleven (9.6%) of the women in the study group and three (2.8%) of the women in the control group were heterozygous carriers of prothrombin gene mutation (OR = 3.66). In assessing with regard to trimesters, 18 (23%) factor V Leiden and 10 (12.8%) prothrombin gene mutations were present in the group of third trimester fetal loss (OR = 4.24 and OR = 5.04, respectively). Three (8.3%) factor V Leiden and one (2.7%) prothrombin gene mutation were detected in women with second trimester fetal loss (OR = 1.28 and OR = 0.40, respectively). Conclusion: Factor V Leiden and prothrombin gene mutations were associated with third trimester nonrecurrent fetal loss. These mutations should be screened in women with third trimester but not second trimester unexplained nonrecurrent late fetal loss.en_US
dc.identifier.citationKarateke, A., Haliloğlu, B. ve Gürbüz, A. (2005). Third trimester nonrecurrent fetal loss is associated with factor V Leiden and prothrombin gene mutations. Journal The Journal of Maternal-Fetal & Neonatal Medicine. 18(5), s. 299-304.en_US
dc.identifier.endpage304en_US
dc.identifier.issue5en_US
dc.identifier.startpage299en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/16390788/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3863
dc.identifier.volume18en_US
dc.institutionauthorHaliloğlu, Berna
dc.language.isoenen_US
dc.publisherNational Library of Medicineen_US
dc.relation.ispartofJournal The Journal of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.isversionof10.1080/14767050500381354en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY02094
dc.titleThird trimester nonrecurrent fetal loss is associated with factor V Leiden and prothrombin gene mutationsen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

Tıp Fakültesi Koleksiyonu