Breast Metastases in Children and Adolescents With Rhabdomyosarcoma: A Large Single-Institution Experience and Literature Review

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dc.contributor.authorKebudi, Rejin
dc.contributor.authorKoc, Begum S.
dc.contributor.authorGorgun, Omer
dc.contributor.authorCelik, Alaaddin
dc.contributor.authorKebudi, Abut
dc.contributor.authorDarendeliler, Emin
dc.date.accessioned2024-07-12T21:58:10Z
dc.date.available2024-07-12T21:58:10Z
dc.date.issued2017en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractIntroduction: Breast metastasis is rare in childhood malignancies. Soft tissue sarcomas, especially rhabdomyosarcomas (RMS), and hematologic neoplasms, such as lymphomas, are the most common tumors that metastasize to the breast, albeit rare. Materials and Methods: All cases with breast metastasis within a cohort of 200 RMS patients followed in our institution during 1990 to 2014 were assessed retrospectively and the literature was reviewed. Results: There were 3 adolescent female patients with breast metastasis. All had alveolar histology. The primary tumors were in the parameningeal sites, extremities, and the perineum, respectively. Two patients had breast metastasis at diagnosis, and 1 during follow-up. In 1 breast lesion, there was a complete response to chemotherapy, and in another there was no response to chemotherapy, and the patient underwent radical mastectomy. In the third patient, there was partial response, and lesions progressed. All patients died with recurrent/progressive disease, 2 with no recurrence in the breast. In the English literature, there are 70 cases including our cases. All but 1 involve female patients, all adolescents, most have alveolar histology and poor prognosis. All had chemotherapy, whereas some had surgery and/or radiotherapy for local treatment. Conclusion: Breast metastasis should be considered in adolescent female patients with RMS. Optimal management is not clear. Besides chemotherapy, mastectomy and radiotherapy should be considered on a case basis.en_US
dc.identifier.doi10.1097/MPH.0000000000000680
dc.identifier.endpage71en_US
dc.identifier.issn1077-4114
dc.identifier.issn1536-3678
dc.identifier.issue1en_US
dc.identifier.pmid27820124en_US
dc.identifier.scopus2-s2.0-84994577825en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MPH.0000000000000680
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8762
dc.identifier.volume39en_US
dc.identifier.wosWOS:000391634100027en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGYen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY09277
dc.subjectrhabdomyosarcomaen_US
dc.subjectbreasten_US
dc.subjectadolescenten_US
dc.titleBreast Metastases in Children and Adolescents With Rhabdomyosarcoma: A Large Single-Institution Experience and Literature Reviewen_US
dc.typeReview
dspace.entity.typePublication

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