The Effect of Captopril on Brain Apoptosis After Burn Injury in Rats

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dc.authorid0000-0003-4968-9761en_US
dc.authorid0000-0003-1005-5526 0000en_US
dc.authorid0002-0021-8400en_US
dc.contributor.authorSaglam, Ibrahim Yaman
dc.contributor.authorOzdamar, Emine Nur
dc.contributor.authorDemiralay, Ebru
dc.contributor.authorSehirli, Ahmet Ozer
dc.contributor.authorSener, Goksel
dc.contributor.authorSaglam, Esra
dc.date.accessioned2024-07-12T21:56:40Z
dc.date.available2024-07-12T21:56:40Z
dc.date.issued2013en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractAIM:The purpose of this study was to determine the possible protective effects of captopril treatment against apoptosis in the brain induced by burn injury. MATERIAL and METHODS: Under ether anaesthesia, Wistar albino rats (200-250 g) were exposed to a 900C (burn) or 250C (sham) water bath for 10 s. The ACE group was treated with i.p. 10 mg/kg captopril immediately after burn injury and this treatment was repeated twice daily. At the end of the 24 hour, brain samples were taken. Apoptotic brain cells marked by terminal deoxynucleotidyl transferase-mediated d-UTP-nick end labeling (TUNEL) were evaluated in the cerebellum and midbrain of rats. RESULTS: Apoptotic cells in the cerebellum were significantly decreased after captopril treatment and found to be lower when compared to the burn group (p<0.001). In the midbrain of rats, the numbers of TUNEL-positive cells and apoptotic bodies were significantly increased in the burn group when compared to the control group (p<0.001).The burn-induced changes were reduced in the captopril-treated burn group (p<0.01). CONCLUSION: Captopril has beneficial effects in burn injury and should be assessed as a therapeutic agent in the management of this condition.en_US
dc.identifier.doi10.5137/1019-5149.JTN.7100-12.2
dc.identifier.endpage371en_US
dc.identifier.issn1019-5149
dc.identifier.issue3en_US
dc.identifier.pmid23756977en_US
dc.identifier.scopus2-s2.0-84878882969en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage366en_US
dc.identifier.trdizinid177003en_US
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.7100-12.2
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8583
dc.identifier.volume23en_US
dc.identifier.wosWOS:000321477200012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTURKISH NEUROSURGICAL SOCen_US
dc.relation.ispartofTURKISH NEUROSURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03710
dc.subjectCaptoprilen_US
dc.subjectApoptosisen_US
dc.subjectBurn injuryen_US
dc.subjectTUNELen_US
dc.titleThe Effect of Captopril on Brain Apoptosis After Burn Injury in Ratsen_US
dc.typeArticle
dspace.entity.typePublication

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