The relation between impaired glucose tolerance and slow coronary flow

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dc.contributor.authorBinak, Emrah
dc.contributor.authorGunduz, Huseyin
dc.contributor.authorSahin, Muslum
dc.contributor.authorKurtoglu, Nuri
dc.contributor.authorDindar, Ismet
dc.date.accessioned2024-07-12T21:49:46Z
dc.date.available2024-07-12T21:49:46Z
dc.date.issued2006en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Impaired glucose tolerance is a preliminary stage in the development of type 2 diabetes mellitus and has been shown to increase the risk of cardiovascular morbidity and mortality in addition to causing endothelial dysfunction. In this study, we sought to determine if impaired glucose tolerance is related to slow coronary flow, an angiographic phenomenon caused by coronary micro and macrovascular endothelial dysfunction. Methods: The population of this prospective study consisted of 28 patients with documented slow coronary flow, defined according to TIMI frame count method, [20 (71.4%) males; 51 +/- 9 years] and 30 patients with normal coronary flow [17 (56.6%) males; 47 +/- 6 years]. All study patients underwent an oral glucose tolerance test after 12 h of fasting. Lipid profile, hemoglobin Ale and systemic blood pressure were measured in all patients. Results: There was no difference between two groups with respect to age, fasting plasma glucose, triglyceride, total cholesterol, high density lipoprotein, low density lipoprotein, hemoglobin Ale, systolic-diastolic blood pressure levels, history of smoking and alcohol consumption. Plasma glucose at 2 h of oral glucose tolerance test was significantly higher in slow coronary flow patients compared to control group (145 +/- 44 vs. 112 +/- 38 mg/dl, P=0.001, respectively). In addition, the number of patients who met the criteria of impaired glucose tolerance was significantly higher in slow coronary flow patient group [16 (57%) vs. 7 (23%), P=0.002, respectively). Conclusions: Our results suggest that impaired glucose tolerance may be an independent etiological factor for slow coronary flow phenomenon. (c) 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijcard.2005.09.007
dc.identifier.endpage146en_US
dc.identifier.issn0167-5273
dc.identifier.issue1en_US
dc.identifier.pmid16297474en_US
dc.identifier.scopus2-s2.0-33746316847en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage142en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijcard.2005.09.007
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8079
dc.identifier.volume111en_US
dc.identifier.wosWOS:000240044400023en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER IRELAND LTDen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF CARDIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01275
dc.subjectslow coronary flowen_US
dc.subjectimpaired glucose toleranceen_US
dc.subjectendotheliumen_US
dc.titleThe relation between impaired glucose tolerance and slow coronary flowen_US
dc.typeArticle
dspace.entity.typePublication

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