Searching Evidences of Stroke in Animal Models: A Review of Discrepancies

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dc.contributor.authorKaya, Ahmet Hilmi
dc.contributor.authorErdogan, Hakan
dc.contributor.authorTasdemiroglu, Erol
dc.date.accessioned2024-07-12T21:58:20Z
dc.date.available2024-07-12T21:58:20Z
dc.date.issued2017en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractSo far, animal models have helped us better understand the pathophysiology of the ischemic brain damage but they could not contribute so much to clinical practice. The discrepancies in results regarding neuroprotective agents in animal experiments compared to clinical trials have not been solved. Various animal models of ischemic stroke have proven efficacy of many neuroprotective agents without any considerable result in phase III clinical trials. As is well known, stroke-related focal cerebral ischemia or cardiac arrest related global cerebral ischemia are major causes of disability and death among human subjects. Animal models are essential to evaluate the therapeutic approaches for humans. In this review, we will try to answer two important questions: 1) Which factors endanger the reliability of experimental studies of stroke on animal models? 2) How can we design our experiments to reflect the neurorestoration and/or neuroprotection mechanisms following ischemic injury, when it comes to human disease?en_US
dc.identifier.doi10.5137/1019-5149.JTN.15373-15.2
dc.identifier.endpage173en_US
dc.identifier.issn1019-5149
dc.identifier.issue2en_US
dc.identifier.pmid27337242en_US
dc.identifier.scopus2-s2.0-85014823770en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage167en_US
dc.identifier.trdizinid220935en_US
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.15373-15.2
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8783
dc.identifier.volume27en_US
dc.identifier.wosWOS:000395614900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTURKISH NEUROSURGICAL SOCen_US
dc.relation.ispartofTURKISH NEUROSURGERYen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY09304
dc.subjectStrokeen_US
dc.subjectAnimal modelsen_US
dc.subjectDiscrepanciesen_US
dc.titleSearching Evidences of Stroke in Animal Models: A Review of Discrepanciesen_US
dc.typeReview
dspace.entity.typePublication

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