The effects of resveratrol on vasospasm after experimental subarachnoidal hemorrhage in rats

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dc.authorid0000-0001-5636-3300en_US
dc.contributor.authorKaraoglan, Alper
dc.contributor.authorAkdemir, Osman
dc.contributor.authorBarut, Seref
dc.contributor.authorKokturk, Sibel
dc.contributor.authorUzun, Hafize
dc.contributor.authorTasyurekli, Mustafa
dc.contributor.authorColak, Ahmet
dc.date.accessioned2024-07-12T21:53:25Z
dc.date.available2024-07-12T21:53:25Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Cerebral vasospasin remains a major cause of morbidity and mortality in patients with SAH. Although many pharmacologic agents and chemicals have been used to prevent and treat CV, the pathogenesis of that condition has not been established. We investigated the efficacy of resveratrol, a stilbene polyphenol and tyrosine kinase inhibitor that occurs naturally in grapes and red wine, in a murine basilar artery vasospasm model. Methods: Forty-two Wistar albino rats were used in this study. The rats were divided into 3 groups of 14 animals each: the sham-operated control group (group 1), the vasospasm group (group 2), and the treatment group (group 3). In groups 2 and 3, autologous blood (0.3 mL) was injected into the cisterna magna. After that injection, the rats in group 3 received an intravenous injection of resveratrol (10 mg/kg) for 72 hours. The evaluation of the response to both the injection of autologous blood and treatment was based on biochemical markers in tissue and serum and on light microscopic findings from the basilar artery, which were collected at different intervals after experimental SAH. Results: Endothelin-1 levels in brain tissue and serum were higher in the vasospasin group than in the control group (P < .05). In group 3 rats, the administration of resveratrol resulted in significantly lower ET-1 values than those in group 2. Brain and serum lipid peroxidation levels were markedly elevated in group 2 rats but decreased significantly after resveratrol treatment in group 3 rats (P < .05). Superoxide dismutase expression in brain tissue and scrum was lower in group 2 rats than in sham-operated controls, and a significant increase in the SOD level was associated with resveratrol treatment. On examination via light microscopy 72 hours after SAH, the mean perimeters of the arterial lumen in groups 1, 2, and 3 were 719 +/- 16, 411.6 +/- 9, and 590.1 +/- 5.6 mu m, respectively. The mean thickness of the arterial wall was as follows: in group 1, 11.1 +/- 0.8 mu m; in group 2, 16.1 +/- 1.2 mu m; and (after resveratrol treatment) in group 3, 13.4 +/- 0.6 mu m Conclusions: The results Of Our study showed that resveratrol induced the relaxation of smooth muscle in the wall of the basilar artery and may be provided with neuroprotection against cerebral ischemia in a rat model. These effects may be associated with the antioxidant and vasodilatory effects of resveratrol, which could prove to be an agent prophylactic against CV and to be therapeutic for individuals who experience that event. (C) 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.surneu.2007.07.031
dc.identifier.endpage343en_US
dc.identifier.issn0090-3019
dc.identifier.issue4en_US
dc.identifier.pmid18207513en_US
dc.identifier.scopus2-s2.0-51349111445en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage337en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.surneu.2007.07.031
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8497
dc.identifier.volume70en_US
dc.identifier.wosWOS:000260201100003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofSURGICAL NEUROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03456
dc.subjectBasilar arteryen_US
dc.subjectCerebral vasospasmen_US
dc.subjectEndothelin-1en_US
dc.subjectLipid peroxidationen_US
dc.subjectResveratrolen_US
dc.subjectSuperoxide dismutaseen_US
dc.titleThe effects of resveratrol on vasospasm after experimental subarachnoidal hemorrhage in ratsen_US
dc.typeArticle
dspace.entity.typePublication

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