Galactose-induced aging model in rat testicular tissue
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
College of Physicians & Surgeons
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To examine whether the D-galactose induced aging model is an appropriate model for further aging research. Study Design: Experimental study. Place and Duration of Study: Aziz Sancar Institute of Experimental Medicine, Istanbul University, Turkey, June 2015- June 2017. Methodology: The study comprises 3 groups of rats. Group I is young control (YC) 5-month-old rats. Group II is 5-monthold rats, which were mimetically aged (MA) for 6 weeks via intraperitoneal D-galactose (60 mg/kg body weight/day, 0.5 mL) administration. Group III is naturally aged (NA) 24-month-old rats. Group I and III received intraperitoneal saline (0.9% 0.5 mL) for 6 weeks as vehicle. Group I and Group II received injections at 21 weeks age and Group III rats 6 weeks before 24 months age. Tissues were harvested when rats became 6.5-month-old (Group I and Group II) and 24-month-old (Group III). Quantitative biochemical analyses of proteins, lipids, DNA biomarkers and Cu, Zn-SOD were conducted. Statistical analysis of the data was conducted using ANOVA, followed by post-hoc Bonferroni test. Results: Higher magnitude of oxidative damage and diminished antioxidant defence capacity were found in both mimetically aged and naturally aged testicular tissues. It is observed that D-galactose aging model group shares significant similarities in terms of impaired redox homeostasis with the naturally aged rats. Conclusion: D-galactose induced testicular aging model successfully mimics aging process. Therefore, D-galactose induced aging model may be used as an accelerated aging model to study the age related alterations and interventions.
Açıklama
Anahtar Kelimeler
Galactose, Natural aging, Mimetic aging, Oxidative stress, Redox homeostasis, Testis
Kaynak
Journal of College of Physicians and Surgeons Pakistan
WoS Q Değeri
Scopus Q Değeri
Cilt
28
Sayı
7
Künye
Aydın, Ş., Yanar, K., Şimşek, B. vd. (2018). Galactose-induced aging model in rat testicular tissue. Journal of College of Physicians and Surgeons Pakistan, College of Physicians & Surgeons. 28(7), s. 501-504.
