Neurotoxic effects of levobupivacaine and fentanyl on rat spinal cord

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dc.authorid0000-0002-6197-7654en_US
dc.contributor.authorAbut, Yesim Cokay
dc.contributor.authorTurkmen, Asti Zengin
dc.contributor.authorMidi, Ahmet
dc.contributor.authorEren, Burak
dc.contributor.authorYener, Nese
dc.contributor.authorNurten, Asiye
dc.date.accessioned2024-07-12T21:53:10Z
dc.date.available2024-07-12T21:53:10Z
dc.date.issued2015en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: The purpose of the study was to compare the neurotoxic effects of intrathecally administered levobupivacaine, fentanyl and their mixture on rat spinal cord. Methods: In experiment, there were four groups with medication and a control group. Rats were injected 15 mu L saline or fentanyl 0.0005 mu g/15 mu L, levobupivacaine 0.25%/15 mu L and fentanyl 0.0005 mu g + levobupivacaine 0.25%/15 mu L intrathecally for four days. Hot plate test was performed to assess neurologic function after each injection at 5th, 30th and 60th min. Five days after last lumbal injection, spinal cord sections between the T5 and T6 vertebral levels were obtained for histologic analysis. A score based on subjective assessment of number of eosinophilic neurons - Red neuron - which means irreversible neuronal degeneration. They reflect the approximate number of degenerating neurons present in the affected neuroanatomic areas as follows: 1, none; 2, 1-20%; 3, 21-40%; 4, 41-60%; and 5, 61-100% dead neurons. An overall neuropathologic score was calculated for each rat by summating the pathologic scores for all spinal cord areas examined. Results: In the results of HPT, comparing the control group, analgesic latency statistically prolonged for all four groups. In neuropathologic investment, the fentanyl and fentanyl + levobupivacaine groups have statistically significant high degenerative neuron counts than control and saline groups. Conclusions: These results suggest that, when administered intrathecally in rats, fentanyl and levobupivacaine behave similar for analgesic action, but fentanyl may be neurotoxic for spinal cord. There was no significant degeneration with levobupivacaine, but fentanyl group has had significant degeneration. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.en_US
dc.identifier.doi10.1016/j.bjane.2013.07.005
dc.identifier.endpage33en_US
dc.identifier.issn0034-7094
dc.identifier.issn1806-907X
dc.identifier.issue1en_US
dc.identifier.pmid25497746en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.bjane.2013.07.005
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8461
dc.identifier.volume65en_US
dc.identifier.wosWOS:000348246300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofREVISTA BRASILEIRA DE ANESTESIOLOGIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03351
dc.subjectLevobupivacaineen_US
dc.subjectNeurotoxicityen_US
dc.subjectFentanylen_US
dc.titleNeurotoxic effects of levobupivacaine and fentanyl on rat spinal corden_US
dc.typeArticle
dspace.entity.typePublication

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