Effects of clopidogrel and high dose aspirin on survival of skin flaps in rats

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dc.authorid0000-0001-8142-8794en_US
dc.contributor.authorAkan, Mithat
dc.contributor.authorÇakır, Barış
dc.contributor.authorMısırlıoğlu, Aykut
dc.contributor.authorYıldırım, Serkan
dc.contributor.authorTaylan, Gaye
dc.contributor.authorAköz, Tayfun
dc.date.accessioned2024-07-12T21:11:04Z
dc.date.available2024-07-12T21:11:04Z
dc.date.issued2005en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractClopidogrel is a new antiplatelet agent with a different mechanism of action from aspirin. It is a thienopyridine derivative that is chemically related to ticlopidine, which irreversibly inhibits platelet aggregation by selectively binding to adenylatecyclase-coupled adenosine diphosphate receptors on the platelet’s surface. Aspirin is an antiplatelet agent that acetylates cyclo-oxygenase and decreases the products of arachidonic acid metabolism, including thromboxane and prostacyclin. Necrosis of a flap is still an important complication in reconstructive surgery. To investigate the effects of clopidogrel or high dose aspirin on the survival of skin flaps, 30 rats were divided into three groups of 10 animals each: a control group, a clopidogrel group, and a high-dose aspirin group. No pharmacological agents were used in the control group. Of the two treated groups, the first was given clopidogrel 50 mg/kg/day and the second aspirin 200 mg/kg/day for three days before the operation. After seven days the viable areas of each flap were evaluated and the mean (SD) percentage in the control group was 47 (6), in the clopidogrel group 63 (4), and in the aspirin group 65 (5). Although the mean area of flaps that survived in the aspirin group was slightly higher than in the clopidogrel group, the difference was not significant.en_US
dc.identifier.citationAkan, M., Çakır, B., Mısırlıoğlu, A., Yıldırım, S., Taylan, G. ve Aköz, T. (2005). Effects of clopidogrel and high dose aspirin on survival of skin flaps in rats. Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. 39(1), s. 7-10.en_US
dc.identifier.endpage10en_US
dc.identifier.issn0284-4311
dc.identifier.issue1en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4326
dc.identifier.volume39en_US
dc.institutionauthorAköz, Tayfun
dc.language.isoenen_US
dc.publisherTaylor and Francis Onlineen_US
dc.relation.ispartofScandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgeryen_US
dc.relation.isversionof10.1080/02844310410017951en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03388
dc.subjectClopidogrelen_US
dc.subjectAspirinen_US
dc.subjectRandom flap viabilityen_US
dc.titleEffects of clopidogrel and high dose aspirin on survival of skin flaps in ratsen_US
dc.typeArticle
dspace.entity.typePublication

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