The vasoactive intestinal polypeptide (VIP) levels at the patients with ankylosing spondylitis and its association with inflammation markers

Basit Öğe Kaydı
dc.authorid0000-0003-3901-4015en_US
dc.authorid0000-0003-2045-1709en_US
dc.authorid0000-0002-4936-3705en_US
dc.contributor.authorNalbant, Selim
dc.contributor.authorÇağıltay, Eylem
dc.contributor.authorŞahan, Burak
dc.contributor.authorTerekeci, Murat Hakan
dc.contributor.authorÖktenli, Çağatay
dc.date.accessioned2024-07-12T21:11:03Z
dc.date.available2024-07-12T21:11:03Z
dc.date.issued2011en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractVasoactive intestinal polypeptide (VIP) is a neuropeptide from secretin/glukagon family. Recently, the importance of VIP is becoming more evident, and it is thought that VIP is playing an important regulatory role between neuroendocrine-immune-gastrointestinal systems. In this study, we have tried to evaluate the potential role of VIP in patients with ankylosing spondylitis (AS). In this study, 40 patients (30 male and 10 female) with AS and 40 healthy controls were included. X-ray examinations and scoring of sacroiliac joints of the patients with AS were done according to 1984 Modified New York Criteria for AS. All patients have been assessed with Bath Ankylosing Spondylitis Disease Activity Index. Platelet counts were significantly higher in study group (P < 0.05) in contrast to levels of the hemoglobin. The mean VIP levels were 4.2 ± 1.8 (pg/mL) for study group and 2.8 ± 0.8 (pg/mL) for controls. These results were statistically significant (P < 0.05). There was not any correlation between plasma VIP levels with CRP, ESR, Hb, BASDAI results and radiological scoring of the patients (P > 0.05) in contrast to our expectations. However, platelet counts and VIP levels were correlated significantly (P = 0.03). Our data demonstrate that VIP tended to be high in patients with AS when compared with healthy subjects and correlated with platelet counts significantly, for the first time at the literature. According to this study, VIP may have potential role in the pathogenesis of AS, and it is a potential candidate for many kinds of therapies.en_US
dc.identifier.citationNalbant, S., Çağıltay, E., Şahan, B., Terekeci, H.M. ve Öktenli, C. (2011). The vasoactive intestinal polypeptide (VIP) levels at the patients with ankylosing spondylitis and its association with inflammation markers. Rheumatology International, SpringerLink. 31(9), s. 1143-1146.en_US
dc.identifier.endpage1146en_US
dc.identifier.issn1437-160X
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1143en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/20340024/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4323
dc.identifier.volume31en_US
dc.language.isoenen_US
dc.publisherSpringerlinken_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.isversionof10.1007/s00296-010-1417-2en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03367
dc.subjectVasoactive intestinal polypeptideen_US
dc.subjectAnkylosing spondylitisen_US
dc.subjectInflammation markersen_US
dc.subjectPlatelet countsen_US
dc.titleThe vasoactive intestinal polypeptide (VIP) levels at the patients with ankylosing spondylitis and its association with inflammation markersen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

Tıp Fakültesi Koleksiyonu