Association between apolipoprotein E genotypes and panic disorder in Turkish population

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dc.authorid0000-0002-7415-2926en_US
dc.authorid0000-0002-9227-9373en_US
dc.authorid0000-0002-3124-0184en_US
dc.contributor.authorGulec-Yilmaz, Seda
dc.contributor.authorGulec, Huseyin
dc.contributor.authorOgut, Dicle Bilge
dc.contributor.authorCetin, Bugra
dc.contributor.authorGormus, Uzay
dc.contributor.authorIsbir, Turgay
dc.date.accessioned2024-07-12T21:52:32Z
dc.date.available2024-07-12T21:52:32Z
dc.date.issued2019en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractAim: In this study, we aimed to investigate possible interactions among the apolipoprotein E (ApoE) and panic disorder (PD), taking into account serum cholesterol levels and subfractions.Methods: ApoE genotyping was performed by real-time polymerase chain reaction in DNA samples of PD patient group (n=45) and healthy control group (n=50). The serum lipid levels, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) subfraction analysis were examined.Results: There was a significant difference of ApoE genotypes in patient and control groups. The E3/E3 genotypes lower whereas E4 allele carriers were significantly higher in PD group ApoE4allele carriers had 3.2-fold higher risk of PD. PD group had significantly lower LDL and HDL levels. In spite of the decreased levels of total LDL, antiatherogenic large LDL subgroup was significantly lower in a patient with PD. Antiatherogenic large HDL and Intermediate HDL levels were lower, while atherogenic small HDL subfraction was significantly higher in PD group. Furthermore, Apo E3/E3 genotype carriers had significantly higher large LDL, HDL, large HDL, intermediate HDL level, and also had highest HDL between all the groups. ApoE4 allele carriers while they had highest atherogenic small HDL level.Conclusion: E4 allele can be associated with PD as an eligible risk factor, the E3/E3 could be a risk-reducing factor for PD. Patients with PD not only had lower LDL and HDL levels but also they have higher atherogenic LDL and HDL subfractions. Also, E3/E3 genotype carriers had convenient but ApoE4 carriers had atherogenic plasma cholesterol levels and subfractions.en_US
dc.identifier.doi10.1080/08039488.2018.1482957
dc.identifier.endpage483en_US
dc.identifier.issn0803-9488
dc.identifier.issn1502-4725
dc.identifier.issue7en_US
dc.identifier.pmid29888635en_US
dc.identifier.scopus2-s2.0-85048378363en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage477en_US
dc.identifier.urihttps://dx.doi.org/10.1080/08039488.2018.1482957
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8397
dc.identifier.volume72en_US
dc.identifier.wosWOS:000456435500004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofNORDIC JOURNAL OF PSYCHIATRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03135
dc.subjectApoEen_US
dc.subjectpolymorphismen_US
dc.subjectpanic disorderen_US
dc.subjectserum cholesterol levelsen_US
dc.titleAssociation between apolipoprotein E genotypes and panic disorder in Turkish populationen_US
dc.typeArticle
dspace.entity.typePublication

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