Estrogen and androgen hormone levels modulate the expression of PIWI interacting rna in prostate and breast cancer

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dc.authorid0000-0003-3771-3277en_US
dc.contributor.authorÖner, Çağrı
dc.contributor.authorTurgut Coşan, Didem
dc.contributor.authorÇolak, Ertuğrul
dc.date.accessioned2024-07-12T21:11:00Z
dc.date.available2024-07-12T21:11:00Z
dc.date.issued2016en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractPIWI interacting RNAs (piRNAs), a member of non-coding RNA, originate from intergenic repetitive regions of the genome. piRNA expressions increase in various cancers and it is thought that this increase could be caused by hormones. We aimed to determine the effects of hormones on piRNA expression in breast and prostate cancer. High viability and a decrease in adhesion were observed at the concentrations of the highest proliferation. Furthermore, an increase in adhesion was also observed in MDA-MB-231 cells. After hormone treatment, while piR-651 expression had increased both breast and prostate cancer cell lines, piR-823 expressions increased in prostate cancer cell lines and only in the breast cancer cell line which was malignant. Thus, it was determined that piR-823 might show different expressions in different type of cancers.en_US
dc.identifier.citationÖner, Ç., Turgut Coşan, D. ve Çolak, E. (2016). Estrogen and androgen hormone levels modulate the expression of PIWI interacting rna in prostate and breast cancer. PLoS ONE, Public Library of Science. 11(7), s. 1-15.en_US
dc.identifier.endpage15en_US
dc.identifier.issn1932-6203
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159044
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4311
dc.identifier.volume11en_US
dc.institutionauthorÖner, Çağrı
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS ONEen_US
dc.relation.isversionof10.1371/journal.pone.0159044en_US
dc.relation.publicationcategoryUlusal Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03284
dc.titleEstrogen and androgen hormone levels modulate the expression of PIWI interacting rna in prostate and breast canceren_US
dc.typeArticle
dspace.entity.typePublication

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