Distinguishing Depressive Pseudodementia from Alzheimer Disease: A Comparative Study of Hippocampal Volumetry and Cognitive Tests

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dc.authorid0000-0003-2016-9965en_US
dc.authorid0000-0003-3868-3137en_US
dc.authorid0000-0001-5974-458Xen_US
dc.authorid0000-0002-5539-2502en_US
dc.authorid0000-0002-2887-9235en_US
dc.contributor.authorSahin, Sevki
dc.contributor.authorOnal, Tugba Okluoglu
dc.contributor.authorCinar, Nilgun
dc.contributor.authorBozdemir, Meral
dc.contributor.authorCubuk, Rahmi
dc.contributor.authorKarsidag, Sibel
dc.date.accessioned2024-07-12T21:46:07Z
dc.date.available2024-07-12T21:46:07Z
dc.date.issued2017en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground and Aim: Depressive pseudodementia (DPD) is a condition which may develop secondary to depression. The aim of this study was to contribute to the differential diagnosis between Alzheimer disease (AD) and DPD by comparing the neurocognitive tests and hippocampal volume. Materials and Methods: Patients who met criteria of AD/DPD were enrolled in the study. All patients were assessed using the Wechsler Memory Scale (WMS), clock-drawing test, Stroop test, Benton Facial Recognition Test (BFRT), Boston Naming Test, Mini-Mental State Examination (MMSE), and Geriatric Depression Scale (GDS). Hippocampal volume was measured by importing the coronal T1-weighted magnetic resonance images to the Vitrea 2 workstation. Results: A significant difference was found between the AD and DPD groups on the WMS test, clock-drawing test, Stroop test, Boston Naming Test, MMSE, GDS, and left hippocampal volume. A significant correlation between BFRT and bilateral hippocampal volumes was found in the AD group. No correlation was found among parameters in DPD patients. Conclusions: Our results suggest that evaluation of facial recognition and left hippocampal volume may provide more reliable evidence for distinguishing DPD from AD. Further investigations combined with functional imaging techniques including more patients are needed. (C) 2017 The Author(s) Published by S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000477759
dc.identifier.endpage239en_US
dc.identifier.issn1664-5464
dc.identifier.issue2en_US
dc.identifier.pmid28868066en_US
dc.identifier.scopus2-s2.0-85021866490en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage230en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000477759
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7892
dc.identifier.volume7en_US
dc.identifier.wosWOS:000410960800005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofDEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00611
dc.subjectAlzheimer diseaseen_US
dc.subjectDepressionen_US
dc.subjectDementiaen_US
dc.subjectCognitionen_US
dc.subjectMagnetic resonance imagingen_US
dc.titleDistinguishing Depressive Pseudodementia from Alzheimer Disease: A Comparative Study of Hippocampal Volumetry and Cognitive Testsen_US
dc.typeArticle
dspace.entity.typePublication

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