Effects of escitalopram on ethanol withdrawal syndrome in rats

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dc.authorid0000-0002-6423-4207en_US
dc.authorid0000-0002-0021-8400en_US
dc.contributor.authorSaglam, Esra
dc.contributor.authorKayir, Hakan
dc.contributor.authorCelik, Turgay
dc.contributor.authorUzbay, Tayfun
dc.date.accessioned2024-07-12T21:58:19Z
dc.date.available2024-07-12T21:58:19Z
dc.date.issued2006en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractThe present study was designed to investigate the effects of escitalopram, a selective serotonin reuptake inhibitor, on ethanol withdrawal syndrome in rats. Adult male Wistar rats (266-278 g) were subjects. Ethanol (7.2%, v/v) was given to rats by a liquid diet for 21 days. Control rats were pair fed with an isocaloric liquid diet containing sucrose as a caloric substitute to ethanol. Escitalopram, (2.5, 5 and 10 mg/kg) and saline were injected to rats intraperitoneally just before ethanol withdrawal. After the second and sixth hours of ethanol withdrawal, rats were observed for 5 min, and withdrawal signs that included locomotor hyperactivity, agitation, stereotyped behavior, wet dog shakes, tremors and audiogenic seizures were recorded or rated. A second series of injections was given 30 min before sixth hour of withdrawal test. Effects of escitalopram on the locomotor activities of the naive (no ethanol-dependent) rats were also evaluated. Escitalopram (5 mg/kg) reduced the increased stereotyped behaviors at the sixth hour of ethanol withdrawal. It inhibited tremors at the second hour of ethanol withdrawal at doses of 5 and 10 mg/kg. Escitalopram (2.5 and 5 mg/kg) also produced some significant attenuations in the incidence of wet dog shakes at the second and sixth hours of the observation period. It was found ineffective on locomotor hyperactivity, agitation and audiogenic seizures. Escitalopram (2.5 and 5 mg/kg) did not cause any significant effect on locomotor activities of the naive rats. Our results suggest that acute escitalopram treatment has some limited beneficial effects on ethanol withdrawal syndrome in rats. (c) 2006 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pnpbp.2006.03.028
dc.identifier.endpage1032en_US
dc.identifier.issn0278-5846
dc.identifier.issue6en_US
dc.identifier.pmid16650516en_US
dc.identifier.scopus2-s2.0-33745257055en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1027en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.pnpbp.2006.03.028
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8770
dc.identifier.volume30en_US
dc.identifier.wosWOS:000239008600006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofPROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRYen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY09286
dc.subjectescitalopramen_US
dc.subjectethanol dependenceen_US
dc.subjectethanol withdrawal syndromeen_US
dc.subjectrat(s)en_US
dc.subjectselective serotonin reuptake inhibitors (SSRIs)en_US
dc.titleEffects of escitalopram on ethanol withdrawal syndrome in ratsen_US
dc.typeReview
dspace.entity.typePublication

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