Effect of platelet-rich plasma on postoperative peritoneal inflammation and adhesions

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dc.contributor.authorKarakaş, Dursun Özgür
dc.contributor.authorDandin, Özgur
dc.contributor.authorMuftuoğlu, Tuba
dc.contributor.authorTihan, Deniz
dc.contributor.authorBal, Ahmet Selim
dc.contributor.authorYıldırım, Sukru
dc.date.accessioned2024-07-12T21:40:09Z
dc.date.available2024-07-12T21:40:09Z
dc.date.issued2021en_US
dc.department[Belirlenecek]en_US
dc.description.abstractIntroduction: Postoperative peritoneal adhesion is an important complication of abdominopelvic surgery. The aim of this study is to reveal the effect of platelet-rich plasma (PRP) on postoperative intraperitoneal inflammation and adhesions. Material and methods: Twenty-four Wistar albino rats were divided into three groups. Cecal incision and suturation was carried out for the experimental model. Intraperitoneally, 3 ml of 0.9% NaCl, 3 ml of PRP, and nothing were applied, and called as saline, PRP, and control groups, respectively. Four subjects in each group were sacrificed at the 3rd and 7th days postoperatively. Adhesion formations and giant cell, lymphocyte/plasmocyte, neutrophil, and histiocyte counts were assessed and hydroxyproline levels were measured in all groups and statistical comparisons were performed. Results: Except giant cell 3rd day scores, PRP had the lowest adhesion, neutrophil, lymphocyte, plasmocyte, histiocyte and fibrosis scores. Both 3rd and 7th days scores of giant cell, neutrophil, lymphocyte, plasmocyte, but only 7th days scores of histiocyte reaction and fibrosis were statistically significant (p < 0.05). Hydroxyproline levels were lower in the saline group at the 3rd day. However, at the 7th day, the levels were lower in the PRP group and no statistically significant difference was found compared to the saline group 3rd day levels (p > 0.05). Conclusions: Platelet-rich plasma has a reducing effect on the postoperative peritoneal adhesions with separation of the damaged tissues, affecting the inflammation, matrix metalloproteinase, plasminogen activation or the other stages of adhesion formation.en_US
dc.identifier.doi10.5114/aoms.2020.94538
dc.identifier.endpage1413en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue5en_US
dc.identifier.pmid34522270en_US
dc.identifier.scopus2-s2.0-85115980928en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1408en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2020.94538
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7165
dc.identifier.volume17en_US
dc.identifier.wosWOS:000692835800028en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY05032
dc.subjectPeritoneumen_US
dc.subjectPostoperativeen_US
dc.subjectInflammationen_US
dc.subjectAdhesionen_US
dc.subjectFormationen_US
dc.subjectPlatelet-Rich Plasmaen_US
dc.titleEffect of platelet-rich plasma on postoperative peritoneal inflammation and adhesionsen_US
dc.typeArticle
dspace.entity.typePublication

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