Mitochondrial depletion in CD4(+) and CD19(+) peripheral lymphocytes in early stage Alzheimer's disease

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dc.authorid0000-0003-3101-626Xen_US
dc.authorid0000-0003-3868-3137en_US
dc.contributor.authorTerzioglu, Gokhan
dc.contributor.authorOrmeci, Burcu
dc.contributor.authorTurksoy, Ozlem
dc.contributor.authorSayman, Ceyhun
dc.contributor.authorCinar, Nilgun
dc.contributor.authorOzturk, Gokcen Akar
dc.contributor.authorDemirel, Gulderen Yanikaya
dc.date.accessioned2024-07-12T21:51:55Z
dc.date.available2024-07-12T21:51:55Z
dc.date.issued2017en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractAlzheimer's disease (AD) may be associated with mitochondrial defects. The aim of the present study was to investigate changes in mitochondrial abundance in peripheral lymphocytes of early and late stage AD patients. We analysed levels of mitochondrial DNA (mtDNA) and mean fluorescence intensity (MFI) of the mitochondria- specific antibody 113-1 in CD4(+), CD8(+), CD19(+) and CD56(+ )peripheral lymphocytes of early and late stage AD by quantitative real-time PCR and flow cytometry, respectively. In early stage AD, the levels of mtDNA were significantly decreased in CD4(+), CD19(+) and CD56(+) peripheral lymphocytes while the MFI of 113-1 staining was significantly decreased in CD4(+) and CD19(+ )cells. Thus, CD4(+) and CD19(+) peripheral lymphocytes of early stage AD patients exhibit mitochondrial depletion, as seen both at the level of DNA and protein.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114S240]en_US
dc.description.sponsorshipThis project was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under grant number 114S240. Gokhan Terzioglu and Burcu Ormeci are co-first authors who contributed to this study equally. The authors declare that there are no conflicts of interest with regard to this research.en_US
dc.identifier.doi10.1016/j.mad.2017.09.003
dc.identifier.endpage29en_US
dc.identifier.issn0047-6374
dc.identifier.issn1872-6216
dc.identifier.pmid28923392en_US
dc.identifier.scopus2-s2.0-85029498018en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage24en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.mad.2017.09.003
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8331
dc.identifier.volume167en_US
dc.identifier.wosWOS:000414108500004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER IRELAND LTDen_US
dc.relation.ispartofMECHANISMS OF AGEING AND DEVELOPMENTen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY02877
dc.subjectAlzheimer's diseaseen_US
dc.subjectLymphocytesen_US
dc.subjectMitochondriaen_US
dc.subjectMitochondrial depletionen_US
dc.subjectmtDNAen_US
dc.titleMitochondrial depletion in CD4(+) and CD19(+) peripheral lymphocytes in early stage Alzheimer's diseaseen_US
dc.typeArticle
dspace.entity.typePublication

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