Agmatine reverses Sub-chronic stress induced Nod-like receptor Protein 3 (NLRP3) activation and cytokine response in rats

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dc.authorid0000-0002-7526-8496en_US
dc.contributor.authorSahin, Ceren
dc.contributor.authorAlbayrak, Ozgur
dc.contributor.authorAkdeniz, Tuğba F.
dc.contributor.authorAkbulut, Zeynep
dc.contributor.authorYanıkkaya Demirel, Gülderen
dc.contributor.authorArıcıoğlu, Feyze
dc.date.accessioned2024-07-12T21:02:06Z
dc.date.available2024-07-12T21:02:06Z
dc.date.issued2016en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractThe activation of Nod-like receptor protein 3 (NLRP3) has lately been implicated in stress and depression as an initiatormechanism required for the production of interleukin (IL)-1band IL-18. Agmatine, an endogenous polyamine widely distributedin mammalian brain, is a novel neurotransmitter/neuromodulator, with antistress, anxiolytic and antidepressant-like effects. In thisstudy, we examined the effect of exogenously administered agmatine on NLRP3 inflammasome pathway/cytokine responses inrats exposed to restraint stress for 7 days. The rats were divided into three groups: stress, stress+agmatine (40 mg/kg; i.p.) andcontrol groups. Agmatine significantly down-regulated the gene expressions of all stress-induced NLRP3 inflammasomecomponents (NLRP3, NF-jB, PYCARD, caspase-1, IL-1band IL-18) in the hippocampus and prefrontal cortex (PFC) andreduced pro-inflammatory cytokine levels not only in both brain regions, but also in serum. Stress-reduced levels of IL-4 andIL-10, two major anti-inflammatory cytokines, were restored back to normal by agmatine treatment in the PFC. The findings ofthe present study suggest that stress-activated NLRP3 inflammasome and cytokine responses are reversed by an acute administra-tion of agmatine. Whether antidepressant-like effect of agmatine can somehow, at least partially, be mediated by the inhibition ofNLRP3 inflammasome cascade and relevant inflammatory responses requires further studies in animal models of depression.en_US
dc.identifier.citationSahin, C., Albayrak, O., Akdeniz, T.F., Akbulut, Z., Yanikkaya Demirel, G. and Aricioglu, F. (2016), Agmatine Reverses Sub-chronic Stress induced Nod-like Receptor Protein 3 (NLRP3) Activation and Cytokine Response in Rats. Basic Clin Pharmacol Toxicol, 119: 367-375.en_US
dc.identifier.endpage375en_US
dc.identifier.issn1742-7843
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage367en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3579
dc.identifier.volume119en_US
dc.institutionauthorAkbulut, Zeynep
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons, Ltden_US
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicologyen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00403
dc.subjectAgmatine Reversesen_US
dc.subjectSub-chronicen_US
dc.subjectStress induceden_US
dc.subjectNod-like Receptoren_US
dc.titleAgmatine reverses Sub-chronic stress induced Nod-like receptor Protein 3 (NLRP3) activation and cytokine response in ratsen_US
dc.typeArticle
dspace.entity.typePublication

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