The prevention of myocardial ultrastructural changes by perindopril, atenolol and amlodipine in chronic alcohol administered rats

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dc.authorid0000-0002-0717-1756en_US
dc.authorid0000-0002-6423-4207en_US
dc.authorid0000-0001-5668-2686en_US
dc.authorid0000-0002-1485-7158en_US
dc.contributor.authorSağ, Cemal
dc.contributor.authorYokuşoğlu, Mehmet
dc.contributor.authorÖzkan, Mustafa
dc.contributor.authorKayır, Hakan
dc.contributor.authorUzun, Mehmet
dc.contributor.authorBaykal, Barış
dc.contributor.authorÖzoğul, Candan
dc.contributor.authorBaysan, Oben
dc.contributor.authorUzbay, Tayfun
dc.date.accessioned2024-07-12T21:10:42Z
dc.date.available2024-07-12T21:10:42Z
dc.date.issued2006en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractThe effects of perindopril, an angiotensin converting enzyme inhibitor, atenolol, a beta adrenergic receptor blocker and amlodipine, a calcium channel blocker were investigated in chronic alcohol administered rats. Adult male Wistar rats (240–320 g) were used in the present study. Alcohol was given to rats by a modified liquid diet for 21 days. Perindopril (2.5 and 5 mg kg?1), atenolol (5 and 10 mg kg?1) and amlodipine (5 and 10 mg kg?1) were injected to rats in different groups intraperitoneally for 21 days. Control rats were pair fed by an isocaloric liquid diet containing sucrose as a caloric substitute for alcohol. Saline was injected to control rats for 21 days. Rats were anesthetized with ether. Their hearts were removed and 1 mm3 samples from left ventricles were fixed. Five fields per heart were examined and photographed with transmission electron microscope. Blood alcohol levels were also measured spectrophotometrically. Daily alcohol consumption of the rats was in a range of 12.09–15.5 g kg?1. Blood alcohol concentrations were found as 145.63 mg dl?1 at 21st day of alcohol consumption. Chronic alcohol consumption caused some marked myocardial injuries. Perindopril and atenolol but not amlodipine produced some significant beneficial effects on alcohol-induced myocardial damages. Our results imply that perindopril and atenolol but not amlodipine have protective effects on heavy chronic alcohol consumption-induced myocardial injury in rats.en_US
dc.identifier.citationSag, C., Yokusoglu, M., Cincik, M., Ozkan, M., Kayir, H., Uzun, M., Baykal, B., Ozogul, C., Baysan, O., & Uzbay, I. T. (2006). The prevention of myocardial ultrastructural changes by perindopril, atenolol and amlodipine in chronic alcohol administered rats. Pharmacological research, Elsevier. 53(2), s. 142–148.en_US
dc.identifier.endpage148en_US
dc.identifier.issn1043-6618
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage142en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1043661805001696?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4275
dc.identifier.volume53en_US
dc.institutionauthorCıncık, Mehmet
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofPharmacological Research Volumeen_US
dc.relation.isversionof10.1016/j.phrs.2005.10.001en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY03230
dc.subjectAmlodipineen_US
dc.subjectPerindoprilen_US
dc.subjectAtenololen_US
dc.subjectAlcohol consumptionen_US
dc.subjectMyocardial ultrastructureen_US
dc.titleThe prevention of myocardial ultrastructural changes by perindopril, atenolol and amlodipine in chronic alcohol administered ratsen_US
dc.typeArticle
dspace.entity.typePublication

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