Melatonin with 1,25-Dihydroxyvitamin D3 Protects against Apoptotic Ischemia-Reperfusion Injury in the Rat Kidney

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dc.authorid0000-0002-5300-4449en_US
dc.authorid0000-0001-6968-5472en_US
dc.authorid0000-0002-0774-2766en_US
dc.contributor.authorSinanoglu, Orhun
dc.contributor.authorSezgin, Gulbuz
dc.contributor.authorOzturk, Guler
dc.contributor.authorTuncdemir, Matem
dc.contributor.authorGuney, Sevin
dc.contributor.authorAksungar, Fehime Benli
dc.contributor.authorYener, Nese
dc.date.accessioned2024-07-12T21:53:05Z
dc.date.available2024-07-12T21:53:05Z
dc.date.issued2012en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractThis study was designed to evaluate the preventive role of melatonin (Mel) and 1,25-dihydroxyvitamin D3 (VD3) in biochemical and apoptotic events leading to tissue injury and renal dysfunction after ischemia-reperfusion (I/R). Thirty male Wistar rats were divided into five groups: sham-operated, I/R, Mel + I/R, VD3 + I/R, and Mel + VD3 + I/R. The rats were intraperitoneally administered with Mel (10 mg/kg), VD3 (0.5 mu g/kg), or Mel (10 mg/kg) plus VD3 (0.5 mu g/kg) each day at 1 week prior to ischemia. Right nephrectomy was initially performed and left renal I/R injury was induced by 45 min of bilateral renal ischemia followed by 45 min of reperfusion. After reperfusion, kidneys and blood were obtained for histopathologic and biochemical evaluation. Mel and VD3 had an ameliorative effect on biochemical parameters such as serum creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, and apoptosis (caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling staining) in the kidneys against renal I/R injury in rats. Additionally, VD3 combined with Mel significantly reduced apoptotic and histological alterations when compared with Mel or VD3 alone. This preventive effect on renal tubular apoptosis was remarkable when Mel was combined with VD3.en_US
dc.description.sponsorshipMaltepe University [2011.04]en_US
dc.description.sponsorshipThis study was funded by Maltepe University (2011.04).en_US
dc.identifier.doi10.3109/0886022X.2012.700887
dc.identifier.endpage1026en_US
dc.identifier.issn0886-022X
dc.identifier.issue8en_US
dc.identifier.pmid22780560en_US
dc.identifier.scopus2-s2.0-84865240215en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1021en_US
dc.identifier.urihttps://dx.doi.org/10.3109/0886022X.2012.700887
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8455
dc.identifier.volume34en_US
dc.identifier.wosWOS:000307438300014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherINFORMA HEALTHCAREen_US
dc.relation.ispartofRENAL FAILUREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03336
dc.subjectmelatoninen_US
dc.subject1,25-dihydroxyvitamin D3en_US
dc.subjectischemia-reperfusionen_US
dc.subjectapoptosisen_US
dc.subjectcaspase-3en_US
dc.subjectkidneyen_US
dc.titleMelatonin with 1,25-Dihydroxyvitamin D3 Protects against Apoptotic Ischemia-Reperfusion Injury in the Rat Kidneyen_US
dc.typeArticle
dspace.entity.typePublication

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