Antioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomy

Basit Öğe Kaydı
dc.authorid0000-0002-6197-7654en_US
dc.contributor.authorKahya, V.
dc.contributor.authorMeric, A.
dc.contributor.authorYazici, M.
dc.contributor.authorYuksel, M.
dc.contributor.authorMidi, A.
dc.contributor.authorGedikli, O.
dc.date.accessioned2024-07-12T21:50:51Z
dc.date.available2024-07-12T21:50:51Z
dc.date.issued2011en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjective: To assess the effect of pomegranate extract on acute inflammation due to myringotomy. Design: Prospective, randomised study. Subjects: Thirty Sprague-Dawley rats were divided into three groups. Group one constituted controls. Group two underwent myringotomy. Group three underwent myringotomy and also received 100 mu l/day pomegranate extract, via gavage, one day before and two days after surgery. Following sacrifice 48 hours after myringotomy, the animals' right ears were used to determine the concentration of reactive oxygen species, using the chemiluminescence method; left ears were used for histological study. Results: Reactive oxygen species levels were significantly decreased in group three compared with group two (p < 0.01). The density of inflammatory cells in group three was significantly less than that in group two (p < 0.01). Lamina propria thickness and vessel density were also significantly decreased in group three compared with group two (p < 0.01). Conclusion: Our results indicate that oral pomegranate extract decreases reactive oxygen species concentration and acute inflammation in the tympanic membrane after myringotomy.en_US
dc.identifier.doi10.1017/S002221511000263X
dc.identifier.endpage375en_US
dc.identifier.issn0022-2151
dc.identifier.issue4en_US
dc.identifier.pmid21349238en_US
dc.identifier.scopus2-s2.0-79958703488en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage370en_US
dc.identifier.urihttps://dx.doi.org/10.1017/S002221511000263X
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8214
dc.identifier.volume125en_US
dc.identifier.wosWOS:000289434100008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCAMBRIDGE UNIV PRESSen_US
dc.relation.ispartofJOURNAL OF LARYNGOLOGY AND OTOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01951
dc.subjectMyringotomyen_US
dc.subjectInflammationen_US
dc.subjectPathologyen_US
dc.subjectAntioxidantsen_US
dc.subjectPunicaceaeen_US
dc.titleAntioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomyen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu