Comparison of the clinicopathological features of flat and polypoid colorectal adenomas that are smaller than or equal to five millimeters

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dc.authorid0000-0002-6197-7654en_US
dc.contributor.authorYener, Nese Arzu
dc.contributor.authorMidi, Ahmet
dc.contributor.authorCelikel, Cigdem Ataizi
dc.date.accessioned2024-07-12T21:56:38Z
dc.date.available2024-07-12T21:56:38Z
dc.date.issued2014en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground/Aims: Colorectal flat adenomas (FAs) may represent a different histogenesis, since their malignant potential is thought to be higher than polypoid adenomas of the same size. In this study, we classified FAs of <= 5 mm into three subgroups-superficially elevated adenomas (SEAs), completely flat adenomas (CFAs), and depressed adenomas (DAs)-based on their low microscopic shapes and compared their clinicopathological features with polypoid tubular adenomas (pTAs) with the same size. Materials and Methods: One hundred one pTAs and 46 FAs with tubular morphology with the same size (<= 5 mm) were studied. Results: The percentages of high-grade dysplasia in FAs and pTAs were 19.56% and 12.87%, respectively. The percentages of the high-grade dysplasia were 28.57%, 13.63%, and 20.00% in the DA, SEA, and CFA subgroups, respectively. FAs had a significantly higher number of normal epithelium at the basal crypts of the lesion than the pTAs (p=0.001). The presence of pericryptal mesenchymal cells was higher in pTAs than the FAs (78.21% vs 10.86%) (p<0.001). Conclusion: Flat adenoma represents a distinct type of colorectal adenoma with special histopathological properties-existence of a normal epithelium at the basal crypts, lack of pericryptal mesenchymal cells, and a high percentage of high-grade dysplasia-especially when it has a depressed shape at low magnification.en_US
dc.identifier.doi10.5152/tjg.2014.2698
dc.identifier.endpage28en_US
dc.identifier.issn1300-4948
dc.identifier.issue1en_US
dc.identifier.pmid24918126en_US
dc.identifier.scopus2-s2.0-84902593325en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage24en_US
dc.identifier.trdizinid221229en_US
dc.identifier.urihttps://dx.doi.org/10.5152/tjg.2014.2698
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8570
dc.identifier.volume25en_US
dc.identifier.wosWOS:000338051700004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAVESen_US
dc.relation.ispartofTURKISH JOURNAL OF GASTROENTEROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03696
dc.subjectFlat colorectal adenomaen_US
dc.subjectnon-polypoid colorectal neoplasiaen_US
dc.subjectcolorectal carcinogenesisen_US
dc.subjectcolorectal adenomaen_US
dc.subjectcolorectal adenomatous polypen_US
dc.titleComparison of the clinicopathological features of flat and polypoid colorectal adenomas that are smaller than or equal to five millimetersen_US
dc.typeArticle
dspace.entity.typePublication

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