Crucial roles of systemic and tissue lipid peroxidation levels and anti-oxidant defences following contrast agent application

Basit Öğe Kaydı
dc.authorid0000-0001-5114-8660en_US
dc.contributor.authorSitar, Güngör
dc.contributor.authorKüçük, Mehmet
dc.contributor.authorSitar, Mustafa Erinç
dc.contributor.authorYaşar, Özgür
dc.contributor.authorAydın, Şeval
dc.contributor.authorYanar, Karolin
dc.contributor.authorÇakatay, Ufuk
dc.contributor.authorBüyükpınarbaşılı, Nur
dc.date.accessioned2024-07-12T21:04:24Z
dc.date.available2024-07-12T21:04:24Z
dc.date.issued2016en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBackground: One of the most important side effects of contrast pharmaceutical agents, which are used very common in routine radiology practice, is contrast induced nephropathy. Even ischemia, oxidative stress and osmolality related cytotoxic effects are considered, the molecular mechanisms underlying this pathology have not been identified completely yet. Objectives: The aim of the current study was to reveal the role of oxidative stress and antioxidant enzymatic defence mechanisms in the aetiopathogenesis of contrast-induced nephropathy. We also studied possible alleviating effects of N-acetylcysteine (NAC), a potent antioxidant, to obtain extra information regarding the molecular mechanisms underlying this pathology. Materials and Methods: This is an clinical-experimental study, This study was conducted of Istanbul/Turkey between September 15, 2012 and April 15, 2013. Three groups of male rats were randomly set up as a control group (C), a 100 mg/kg intraperitoneal NAC + 7 mL/kg contrast agent group (N + CIN) and a 7 mL/kg intraperitoneal contrast agent group (CIN). They were placed in individual metabolic cages 48 hours after agent administration to obtain 24-hour urine samples. Renal function tests (albumin, urea, creatinine, total protein) were conducted, oxidative stress parameters (Cu, Zn superoxide dismutase activity - Cu, Zn-SOD; advanced oxidation protein products - AOPP; protein carbonyls - PCO; total thiol groups - T-SH; and lipid hydroperoxides -LHP) were measured and tissues were analysed histopathologically. Results: Compared with the control group, groups CIN and N + CIN had significantly higher urea and LHP levels (P < 0.05 and P < 0.001, respectively) and significantly lower Cu, Zn-SOD activity and creatinine clearance (P < 0.05). There was no statistically significant difference between the groups in PCO or AOPP levels despite differences in descriptive statistics. Conclusions: Contrast-agent-induced nephropathic changes are more closely related to the magnitude of lipid peroxidation than protein oxidation.en_US
dc.identifier.citationSitar, G., Küçük, M., Sitar, M.E., Yaşar, Ö., Aydın, Ş., Yanar, K., Çakatay, U. ve Büyükpınarbaşılı, N. (2016). Crucial roles of systemic and tissue lipid peroxidation levels and anti-oxidant defences following contrast agent application. Iranian Red Crescent Medical Journal, National Library of Medicine. 18(6), s. 1-9.en_US
dc.identifier.endpage9en_US
dc.identifier.issn2074-1812
dc.identifier.issue6en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010857/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3781
dc.identifier.volume18en_US
dc.institutionauthorSitar, Mustafa Erinç
dc.language.isoenen_US
dc.publisherNational Library of Medicineen_US
dc.relation.ispartofIranian Red Crescent Medical Journalen_US
dc.relation.isversionof10.5812/ircmj.37331en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY01712
dc.subjectContrast Mediaen_US
dc.subjectLipid Peroxidationen_US
dc.subjectNephropathyen_US
dc.subjectOxidative Stressen_US
dc.subjectOxidation Proteinen_US
dc.titleCrucial roles of systemic and tissue lipid peroxidation levels and anti-oxidant defences following contrast agent applicationen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

Tıp Fakültesi Koleksiyonu