Therapeutic efficacy of SJA6017, a calpain inhibitor, in rat spinal cord injury

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dc.contributor.authorAkdemir, Osman
dc.contributor.authorUcankale, Murat
dc.contributor.authorKaraoglan, Alper
dc.contributor.authorBarut, Seref
dc.contributor.authorSagmanligil, Ayhan
dc.contributor.authorBilguvar, Kaya
dc.contributor.authorCirakoglu, Beyazit
dc.contributor.authorSahan, Elife
dc.contributor.authorColak, Ahmet
dc.date.accessioned2024-07-12T21:50:38Z
dc.date.available2024-07-12T21:50:38Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractApoptosis is an important element of the secondary processes that occur after spinal cord injury. Calpain and caspases are key proteases in apoptotic death. We evaluated the neuroprotective effects of SJA6017 (a calpain inhibitor) and measured functional recovery in a rat spinal cord injury model. Thirty Wistar albino rats were divided into three groups of 10 animals each: sham-operated (group 1), trauma control (group 2) and trauma-plus-SJA6017 treatment (group 3). Spinal cord trauma was produced in the thoracic region of the animals. Rats in group 3 received SJA6017 1 min after trauma. Treatment efficacy was evaluated after injury using light microscopy and TUNEL staining. Neurological performance was assessed using a inclined plane and a modified version of the Tarlov's grading scale. Group 2 rats showed moderate traums with widespread edema, hemorrhage, vascular thrombi and necrosis 24 h after injury. Group 3 rats had significantly reduced tissue injury and apoptosis. Tarlov scores revealed that group 3 rats also had ameliorated recovery of limb function. Our results demonstrate that treatment with SJA6017 reduces apoptotic cell death, preserves spinal cord tissue and improves functional outcome. Treating calpain-induced apoptosis with this agent may be a feasible therapeutic strategy for patients with spinal cord injury. (c) 2007 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jocn.2007.08.011
dc.identifier.endpage1136en_US
dc.identifier.issn0967-5868
dc.identifier.issue10en_US
dc.identifier.pmid18656362en_US
dc.identifier.scopus2-s2.0-50249159454en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1130en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jocn.2007.08.011
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8167
dc.identifier.volume15en_US
dc.identifier.wosWOS:000259324800012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofJOURNAL OF CLINICAL NEUROSCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01845
dc.subjectapoptosisen_US
dc.subjectcalpainsen_US
dc.subjectprogrammed cell deathen_US
dc.subjectspinal cord injuryen_US
dc.titleTherapeutic efficacy of SJA6017, a calpain inhibitor, in rat spinal cord injuryen_US
dc.typeArticle
dspace.entity.typePublication

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