Age-related changes in the rat brain mitochondrial antioxidative enzyme ratios: Modulation by melatonin

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dc.authorid0000-0002-9680-1560en_US
dc.authorid0000-0001-6968-5472en_US
dc.contributor.authorOzturk, Guler
dc.contributor.authorAkbulut, K. Gonca
dc.contributor.authorGuney, Sevin
dc.contributor.authorAcuna-Castroviejo, Dario
dc.date.accessioned2024-07-12T21:46:57Z
dc.date.available2024-07-12T21:46:57Z
dc.date.issued2012en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractOxidative stress is an important factor for aging. The antioxidative enzymes glutathione peroxidase (GPx), glutathione reductase (GRd) and superoxide dismutase (SOD) play a crucial role protecting the organism against the age-dependent oxidative stress. Glutathione (GSH) is present in nearly all living cells. GSH is one of the main antioxidants in the cell and it serves several physiological functions. Our purpose was to evaluate the age-related changes in mitochondrial GPx, GRd and SOD activities, and mitochondrial GSH pool in the brains of young (3 months) and aged rats (24 months). We also investigated whether melatonin administration influences these brain mitochondrial enzyme activities and GSH levels in young and aged rats. The results showed that GPx activity increased with age, whereas melatonin treatment decreased GPx activity in the aged rats at levels similar to those in young and young + melatonin groups. The activities of GRd and SOD, however, did not change with age. But, melatonin treatment increased SOD activity in the aged rats. GSH levels, which also increased with age, were not modified by melatonin treatment. The reduction in the SOD/GPx and GR/GPx ratios with age was prevented by melatonin administration. Together, our results suggest that the age-related oxidative stress in rat brain mitochondria is more apparent when the antioxidant enzyme ratios are analyzed instead of their absolute values. The antioxidative effects of melatonin were also supported by the recovery of the enzyme ratios during aging. (C) 2012 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipGazi University [01/201011]en_US
dc.description.sponsorshipThis study was funded by Gazi University (01/201011).en_US
dc.identifier.doi10.1016/j.exger.2012.06.011
dc.identifier.endpage711en_US
dc.identifier.issn0531-5565
dc.identifier.issue9en_US
dc.identifier.pmid22796061en_US
dc.identifier.scopus2-s2.0-84864928432en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage706en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.exger.2012.06.011
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7974
dc.identifier.volume47en_US
dc.identifier.wosWOS:000307660700007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofEXPERIMENTAL GERONTOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00903
dc.subjectMelatoninen_US
dc.subjectAgingen_US
dc.subjectAntioxidanten_US
dc.subjectMitochondriaen_US
dc.subjectBrainen_US
dc.subjectRaten_US
dc.titleAge-related changes in the rat brain mitochondrial antioxidative enzyme ratios: Modulation by melatoninen_US
dc.typeArticle
dspace.entity.typePublication

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