An analysis on the roles of angiogenesis-related factors including serum vitamin D, soluble endoglin (sEng), soluble fms-like tyrosine kinase 1 (sFlt1), and vascular endothelial growth factor (VEGF) in the diagnosis and severity of late-onset preeclampsia

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dc.authorid0000-0002-5344-9739en_US
dc.authorid0000-0001-5278-0174en_US
dc.contributor.authorCim, Numan
dc.contributor.authorKurdoglu, Mertihan
dc.contributor.authorEge, Serhat
dc.contributor.authorYoruk, Ibrahim
dc.contributor.authorYaman, Gorkem
dc.contributor.authorYildizhan, Recep
dc.date.accessioned2024-07-12T21:50:54Z
dc.date.available2024-07-12T21:50:54Z
dc.date.issued2017en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractAim: The aim of this study was to evaluate the roles of proangiogenic factors including serum vitamin D and vascular endothelial growth factor (VEGF) and anti-angiogenic factors including soluble endoglin (sEng) and soluble fms-like tyrosine kinase 1 (sFlt1) in the diagnosis and severity of late-onset preeclampsia. Materials and methods: The study was conducted at Yuzuncu Yil University Research and Education Hospital Department of Gynecology and Obstetrics. The study included a patient group of 40 women with late-onset preeclampsia who were pregnant at >= 32 weeks of gestation according to the last menstrual period (LMP) or ultrasonographic fetal biometric measurement and a control group of 40 healthy pregnant women who presented to our clinic for routine pregnancy examination and were at the same age and gestational period with those in the patient group. The two groups were compared in terms of maternal age, gravida, parity, week of gestation, systolic/diastolic blood pressure, total protein in spot urine sample, 24-h urine protein, white blood cell (WBC), hemoglobin (Hgb), platelet count, urea, creatinine, liver function tests (AST, ALT, LDH), vitamin D-3, 25(OH) vitamin D-3, 1,25(OH) vitamin D-3, sEng, sFlt1, and VEGF levels, mode of delivery, the infant APGAR score at 1 and 5 min after delivery, and infant weight at delivery. Results: The groups were similar in terms of age, gravida, parity, week of gestation, serum vitamin D-3, 25(OH) vitamin D-3, 1,25(OH)(2) vitamin D-3 and VEGF levels, and infant weight at delivery (p > 0.05). Systolic/diastolic blood pressure, total protein in spot urine sample, 24-h urine protein, WBC, Hgb, serum urea, creatine, AST, ALT, and LDH were significantly higher in the preeclamptic group compared to the healthy group (p < 0.05). However, thrombocyte level and the APGAR score at 1 and 5 min after delivery were significantly lower in the preeclamptic group compared to the healthy group (p < 0.05). No significant correlation was found between serum sEng, sFlt1, VEGF, vitamin D-3, 25(OH) vitamin D-3, and 1,25(OH)(2) vitamin D-3 levels. The sEng level was higher in the women with severe preeclampsia compared to the women with mild preeclampsia (p < 0.05) and no significant difference was observed in serum sFlt1, VEGF, vitamin D-3, 25(OH) vitamin D-3, and 1,25(OH)(2) vitamin D-3 levels between the subgroups of preeclampsia (p > 0.05). Conclusion: Both sEng and sFlt1 levels are remarkably high in patients with late-onset preeclampsia; however, only sEng may be a useful tool in the determination of the severity of preeclampsia.en_US
dc.description.sponsorshipYuzuncu Yil University Directorate of Scientific Research Projects [2008-TFU-048]en_US
dc.description.sponsorshipThis study was financially supported by Yuzuncu Yil University Directorate of Scientific Research Projects (Project No: 2008-TFU-048).en_US
dc.identifier.doi10.1080/14767058.2016.1219986
dc.identifier.endpage1607en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue13en_US
dc.identifier.pmid27658884en_US
dc.identifier.scopus2-s2.0-84988660434en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1602en_US
dc.identifier.urihttps://dx.doi.org/10.1080/14767058.2016.1219986
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8219
dc.identifier.volume30en_US
dc.identifier.wosWOS:000401486600020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01961
dc.subjectPreeclampsiaen_US
dc.subjectsoluble endoglinen_US
dc.subjectsoluble fms-like tyrosine kinase 1en_US
dc.subjectvascular endothelial growth factoren_US
dc.subjectangiogenesisen_US
dc.subjectvitamin Den_US
dc.titleAn analysis on the roles of angiogenesis-related factors including serum vitamin D, soluble endoglin (sEng), soluble fms-like tyrosine kinase 1 (sFlt1), and vascular endothelial growth factor (VEGF) in the diagnosis and severity of late-onset preeclampsiaen_US
dc.typeArticle
dspace.entity.typePublication

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