Homocysteine Levels and Echocardiographic Findings in Obstructive Sleep Apnea Syndrome

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dc.authorid0000-0003-3311-3338en_US
dc.authorid0000-0001-7360-8269en_US
dc.contributor.authorSariman, Nesrin
dc.contributor.authorLevent, Ender
dc.contributor.authorAksungar, Fehime Benli
dc.contributor.authorSoylu, Akin Cem
dc.contributor.authorBektas, Osman
dc.date.accessioned2024-07-12T21:53:08Z
dc.date.available2024-07-12T21:53:08Z
dc.date.issued2010en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: The obstructive sleep apnea syndrome (OSAS) is characterized by repeated upper airway obstruction during sleep together with decreases in oxygen saturation leading to a series of pathological events, primarily in the cardiovascular system. Elevated plasma homocysteine levels have recently been considered as an independent risk factor for vascular disease, and increased levels are attributed to cardiovascular diseases. Objectives: We aimed to investigate the possible relationship between homocysteine levels and echocardiographic findings in OSAS patients at different stages of disease. Methods: Thirty-eight patients (23 males and 15 females) with polysomnographically verified OSAS (mean age, 49 +/- 12 years, range 27-74) and a mean body mass index of 31.27 +/- 5.24 kg/m(2) (range 22.60-47.90) were prospectively studied. Plasma levels of homocysteine, cholesterols, triglycerides, vitamin B(12) and high-sensitive C-reactive protein (hsCRP), as well as echocardiographic and lung function parameters were assessed. Results: Homocysteine levels were elevated in all OSAS groups and were statistically significantly different between the mild and moderate/severe groups. Significant differences were present between the variables nocturnal oxygen desaturation (NOD), respiratory arousal and light sleep among the mild and moderate/severe groups. We found a significant positive correlation between homocysteine levels and NOD duration, and hsCRP levels were positively correlated with the apnea-hypopnea index and NOD duration. Conclusions: In all OSAS groups, homocysteine levels were elevated regardless of the presence of cardiac dysfunction. Echocardiographic abnormalities were primarily left-ventricular (LV) hypertrophy and LV diastolic dysfunction and could be observed in all OSAS severity groups. Copyright (C) 2009 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000210429
dc.identifier.endpage45en_US
dc.identifier.issn0025-7931
dc.identifier.issue1en_US
dc.identifier.pmid19339768en_US
dc.identifier.scopus2-s2.0-73349101849en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000210429
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8458
dc.identifier.volume79en_US
dc.identifier.wosWOS:000271536000007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofRESPIRATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03346
dc.subjectC-reactive proteinen_US
dc.subjectEchocardiographyen_US
dc.subjectHomocysteineen_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.titleHomocysteine Levels and Echocardiographic Findings in Obstructive Sleep Apnea Syndromeen_US
dc.typeArticle
dspace.entity.typePublication

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