Protective Effect of Melatonin and 1,25-Dihydroxyvitamin D3 on Renal Ischemia-Reperfusion Injury in Rats

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dc.authorid0000-0002-5300-4449en_US
dc.authorid0000-0001-6968-5472en_US
dc.authorid0000-0002-0774-2766en_US
dc.contributor.authorSezgin, Gulbuz
dc.contributor.authorOzturk, Guler
dc.contributor.authorGuney, Sevin
dc.contributor.authorSinanoglu, Orhun
dc.contributor.authorTuncdemir, Matem
dc.date.accessioned2024-07-12T21:53:06Z
dc.date.available2024-07-12T21:53:06Z
dc.date.issued2013en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractIschemia-reperfusion (I/R) injury induces the generation of reactive oxygen species (ROS) which affect many organs. This study was designed to investigate the roles of melatonin and 1,25-dihydroxyvitamin D-3 (VD3) on renal I/R injury. Thirty male Wistar albino rats were divided into five groups: group 1, control; group 2, right nephrectomy (RN) + I/R in the contralateral kidney; group 3, melatonin + RN + I/R; group 4, VD3 + RN + I/R; and group 5, melatonin + VD3 + RN + I/R. Melatonin (10 mg/kg), VD3 (0.5 mu g/kg), and melatonin plus VD3 were injected intraperitoneally for 7 days before renal I/R. After 7 days, right nephrectomy was initially performed and left renal artery was clamped for 45 min. After 45-min reperfusion, the serum and kidney tissue samples were obtained for assays. Melatonin and VD3 had an ameliorative effect on biochemical parameters such as serum creatinine (SCr) and blood urea nitrogen (BUN). Renal tissue malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO) levels, and superoxide dismutase (SOD) activity were determined. Renal I/R decreased the kidney tissue GSH levels and SOD activity and increased the NO levels as compared with control group. However, melatonin and VD3 and melatonin plus VD3 treatment significantly increased the tissue GSH levels and SOD activity and decreased the NO levels compared with those of I/R group. Meanwhile, MDA levels were not different between the control and I/R groups. But, MDA levels decreased in all treated groups compared to I/R and control groups. These data support that melatonin and VD3 have beneficial effects on renal injury.en_US
dc.description.sponsorshipMaltepe University [2011-04]en_US
dc.description.sponsorshipThis study was funded by Maltepe University (2011-04).en_US
dc.identifier.doi10.3109/0886022X.2012.760409
dc.identifier.endpage379en_US
dc.identifier.issn0886-022X
dc.identifier.issue3en_US
dc.identifier.pmid23356461en_US
dc.identifier.scopus2-s2.0-84875030570en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage374en_US
dc.identifier.urihttps://dx.doi.org/10.3109/0886022X.2012.760409
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8456
dc.identifier.volume35en_US
dc.identifier.wosWOS:000316123900012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherINFORMA HEALTHCAREen_US
dc.relation.ispartofRENAL FAILUREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03337
dc.subjectmelatoninen_US
dc.subject1,25-dihydroxyvitamin D3en_US
dc.subjectischemia-reperfusionen_US
dc.subjectkidneyen_US
dc.subjectantioxidant/oxidant statusen_US
dc.titleProtective Effect of Melatonin and 1,25-Dihydroxyvitamin D3 on Renal Ischemia-Reperfusion Injury in Ratsen_US
dc.typeArticle
dspace.entity.typePublication

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