Results of paclitaxel (day 1 and 8) and carboplatin given on every three weeks in advanced (stage III-IV) non-small cell lung cancer

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dc.authorid0000-0001-8650-299Xen_US
dc.authorid0000-0002-1013-5676en_US
dc.authorid0000-0003-3550-9993en_US
dc.authorid0000-0002-4075-6692en_US
dc.authorid0000-0001-7467-4022en_US
dc.authorid0000-0001-6162-1802en_US
dc.contributor.authorYumuk, Perran Fulden
dc.contributor.authorTurhal, Nazım Serdar
dc.contributor.authorGümüş, Mahmut
dc.contributor.authorHatabay, Nilgün F.
dc.contributor.authorÖzkan, Alper
dc.contributor.authorSalepçi, Taflan
dc.contributor.authorAliustaoğlu, Mehmet
dc.contributor.authorAhıskalı, Rengin
dc.date.accessioned2024-07-12T21:02:10Z
dc.date.available2024-07-12T21:02:10Z
dc.date.issued2005en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBackground Both paclitaxel (P) and carboplatin (C) have significant activity in non-small cell lung cancer (NSCLC). The weekly administration of P is active, dose intense, and has a favorable toxicity profile. We retrospectively reviewed the data of 51 consecutive patients receiving C and day 1 and 8 P chemotherapy (CT) regimen in advanced stage NSCLC to evaluate the efficacy and toxicity. Methods Patients treated in our institutions having pathologically proven NSCLC, no CNS metastases, adequate organ function and performance status (PS) ECOG 0–2 were given P 112.5 mg/m2 intravenously (IV) over 1 hour on day 1 and 8, followed by C AUC 5 IV over 1 hour, repeated in every three weeks. PC was given for maximum of 6 cycles. Results Median age was 58 (age range 39–77) and 41 patients (80%) were male. PS was 0/1/2 in 29/17/5 patients and stage was IIIA/IIIB/IV in 3/14/34 patients respectively. The median number of cycles administered was 3 (1–6). Seven patients (14%) did not complete the first 3 cycles either due to death, progression, grade 3 hypersensitivity reactions to P or lost to follow up. Best evaluable response was partial response (PR) in 45% and stable disease (SD) in 18%. Twelve patients (24%) received local RT. Thirteen patients (25%) received 2nd line CT at progression. At a median follow-up of 7 months (range, 1–20), 25 (49%) patients died and 35 patients (69%) progressed. Median overall survival (OS) was 11 ± 2 months (95% CI; 6 to 16), 1-year OS ratio was 44%. Median time to progression (TTP) was 6 ± 1 months (95% CI; 4 to 8), 1-year progression free survival (PFS) ratio was 20%. We observed following grade 3 toxicities: asthenia (10%), neuropathy (4%), anorexia (4%), anemia (4%), hypersensitivity to P (2%), nausea/vomiting (2%), diarrhea (2%) and neutropenia (2%). Two patients (4%) died of febrile neutropenia. Doses of CT were reduced or delayed in 12 patients (24%). Conclusions P on day 1 and 8 and C every three weeks is practical and fairly well tolerated outpatient regimen. This regimen seems to be comparably active to regimens given once in every three weeks.en_US
dc.identifier.citationYumuk, P.F., Turhal, N.S., Gumus, M., Hatabay, N.F., Turken, O., Ozkan, A., Salepci, T., Aliustaoglu, M. ve Ahiskalı, R. (2005). Results of paclitaxel (day 1 and 8) and carboplatin given on every 3 weeks in advanced stage (III-IV) non-small cell lung cancer. BMC Cancer, Springer Nature. 25(5), s. 1-10.en_US
dc.identifier.endpage10en_US
dc.identifier.issn1471-2407
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC548151/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3589
dc.identifier.volume25en_US
dc.institutionauthorTürken, Orhan
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofBMC Canceren_US
dc.relation.isversionof10.1186/1471-2407-5-10en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY00436
dc.subjectOverall Survivalen_US
dc.subjectPaclitaxelen_US
dc.subjectGemcitabineen_US
dc.subjectFebrile Neutropeniaen_US
dc.subjectVinorelbineen_US
dc.titleResults of paclitaxel (day 1 and 8) and carboplatin given on every three weeks in advanced (stage III-IV) non-small cell lung canceren_US
dc.typeArticle
dspace.entity.typePublication

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