Hydrodynamic cavitation kills prostate cells and ablates benign prostatic hyperplasia tissue

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dc.authorid0000-0002-0690-0988en_US
dc.authorid0000-0001-7739-2346en_US
dc.authorid0000-0001-6283-6717en_US
dc.authorid0000-0003-4062-9519en_US
dc.contributor.authorItah, Zeynep
dc.contributor.authorOral, Ozlem
dc.contributor.authorPerk, Osman Yavuz
dc.contributor.authorSesen, Muhsincan
dc.contributor.authorDemir, Ebru
dc.contributor.authorErbil, Secil
dc.contributor.authorDogan-Ekici, A. Isin
dc.contributor.authorEkici, Sinan
dc.contributor.authorKosar, Ali
dc.contributor.authorGozuacik, Devrim
dc.date.accessioned2024-07-12T21:46:57Z
dc.date.available2024-07-12T21:46:57Z
dc.date.issued2013en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractHydrodynamic cavitation is a physical phenomenon characterized by vaporization and bubble formation in liquids under low local pressures, and their implosion following their release to a higher pressure environment. Collapse of the bubbles releases high energy and may cause damage to exposed surfaces. We recently designed a set-up to exploit the destructive nature of hydrodynamic cavitation for biomedical purposes. We have previously shown that hydrodynamic cavitation could kill leukemia cells and erode kidney stones. In this study, we analyzed the effects of cavitation on prostate cells and benign prostatic hyperplasia (BPH) tissue. We showed that hydrodynamic cavitation could kill prostate cells in a pressure- and time-dependent manner. Cavitation did not lead to programmed cell death, i.e. classical apoptosis or autophagy activation. Following the application of cavitation, we observed no prominent DNA damage and cells did not arrest in the cell cycle. Hence, we concluded that cavitation forces directly damaged the cells, leading to their pulverization. Upon application to BPH tissues from patients, cavitation could lead to a significant level of tissue destruction. Therefore similar to ultrasonic cavitation, we propose that hydrodynamic cavitation has the potential to be exploited and developed as an approach for the ablation of aberrant pathological tissues, including BPH.en_US
dc.description.sponsorshipSabanci University [IACF09-00642]; Scientific and Technological Research Council of Turkey (TUBITAK) [111M621]; EMBO; Turkish Academy of Sciences (TUBA) GEBIP Awarden_US
dc.description.sponsorshipThis work was supported by Sabanci University Internal Grant for Research Program under Grant IACF09-00642 and the Scientific and Technological Research Council of Turkey (TUBITAK) 1001 Grant (Project No: 111M621). D. G. is a recipient of EMBO Strategical Development and Installation Grant (EMBO-SDIG) and D. G. and A. K. are recipients of a Turkish Academy of Sciences (TUBA) GEBIP Award. The authors have no financial conflict of interests.en_US
dc.identifier.doi10.1177/1535370213503273
dc.identifier.endpage1250en_US
dc.identifier.issn1535-3702
dc.identifier.issn1535-3699
dc.identifier.issue11en_US
dc.identifier.pmid24047796en_US
dc.identifier.scopus2-s2.0-84887168918en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1242en_US
dc.identifier.urihttps://dx.doi.org/10.1177/1535370213503273
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7973
dc.identifier.volume238en_US
dc.identifier.wosWOS:000326652700005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherROYAL SOC MEDICINE PRESS LTDen_US
dc.relation.ispartofEXPERIMENTAL BIOLOGY AND MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00902
dc.subjectHydrodynamic cavitationen_US
dc.subjectcell deathen_US
dc.subjectautophagyen_US
dc.subjectprostate cellsen_US
dc.subjectbenign prostatic hyperplasiaen_US
dc.subjecttissue ablationen_US
dc.titleHydrodynamic cavitation kills prostate cells and ablates benign prostatic hyperplasia tissueen_US
dc.typeArticle
dspace.entity.typePublication

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