A Multicenter Study of 1144 Patients with Cerebral Venous Thrombosis: The VENOST Study

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dc.authorid0000-0001-6397-9293en_US
dc.authorid0000-0002-6198-2883en_US
dc.authorid0000-0002-4961-4332en_US
dc.authorid0000-0001-8142-913Xen_US
dc.authorid0000-0002-9655-9487en_US
dc.authorid0000-0002-3279-1842en_US
dc.authorid0000-0002-6148-3814en_US
dc.authorid0000-0002-5605-2980en_US
dc.authorid0000-0002-2270-9868en_US
dc.contributor.authorDuman, Taskin
dc.contributor.authorUluduz, Derya
dc.contributor.authorMidi, Ipek
dc.contributor.authorBektas, Hesna
dc.contributor.authorKablan, Yuksel
dc.contributor.authorGoksel, Basak K.
dc.contributor.authorMilanlioglu, Aysel
dc.contributor.authorOrken, Dilek Necioglu
dc.contributor.authorAluclu, Ufuk
dc.contributor.authorColakoglu, Sena
dc.contributor.authorTufekci, Ahmet
dc.contributor.authorBakar, Mustafa
dc.contributor.authorNazliel, Bijen
dc.contributor.authorTascilar, Nida
dc.contributor.authorGoksan, Baki
dc.contributor.authorKozak, Hasan Huseyin
dc.contributor.authorDemir, Serkan
dc.contributor.authorMisirli, Cemile Handan
dc.contributor.authorKucukoglu, Hayriye
dc.contributor.authorCinar, Nilgun
dc.contributor.authorDomac, Fusun Mayda
dc.contributor.authorOzturk, Serefnur
dc.contributor.authorYayla, Vildan
dc.contributor.authorKarahan, Ali Yavuz
dc.contributor.authorAfsar, Nazire
dc.contributor.authorGoksu, Eylem Ozaydin
dc.contributor.authorMengulluoglu, Necdet
dc.contributor.authorAytac, Emrah
dc.contributor.authorYesilot, Nilufer
dc.contributor.authorInce, Birsen
dc.contributor.authorYalin, Ozgur Osman
dc.contributor.authorOruc, Serdar
dc.contributor.authorDemirci, Seden
dc.contributor.authorSenol, Mehmet Guney
dc.contributor.authorYilmaz, Arda
dc.contributor.authorGokce, Mustafa
dc.contributor.authorKuspeci, Ozge Yilmaz
dc.contributor.authorUzuner, Gulnur
dc.contributor.authorCaglayan, Hale Zeynep Batur
dc.contributor.authorAcikgoz, Mustafa
dc.contributor.authorZeydan, Burcu
dc.contributor.authorOzdag, Fatih
dc.contributor.authorBaybas, Sevim
dc.contributor.authorEkmekci, Hakan
dc.contributor.authorCabalar, Murat
dc.contributor.authorYaman, Mehmet
dc.contributor.authorYurekli, Vedat Ali
dc.contributor.authorTekeli, Hakan
dc.contributor.authorGenc, Hamit
dc.contributor.authorUtku, Uygar
dc.contributor.authorTokuc, Firdevs Ezgi Ucan
dc.contributor.authorUzuner, Nevzat
dc.date.accessioned2024-07-12T21:51:32Z
dc.date.available2024-07-12T21:51:32Z
dc.date.issued2017en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Based on a number of small observational studies, cerebral venous sinus thrombosis has diverse clinical and imaging features, risk factors, and variable outcome. In a large, multicenter cerebral venous thrombosis (VENOST) study, we sought to more precisely characterize the clinical characteristics of Caucasian patients. Methods: All data for the VENOST study were collected between the years 2000 and 2015 from the clinical follow-up files. Clinical and radiological characteristics, risk factors, and outcomes were compared in terms of age and sex distribution. Results: Among 1144 patients 68% were women, and in older age group (>50 years) male patients were more prevalent (16.6% versus 27.8%). The most frequent symptoms were headache (89.4%) and visual field defects (28.9%) in men, and headache (86.1%) and epileptic seizures (26.8%) in women. Gynecological factors comprised the largest group in women, in particular puerperium (18.3%). Prothrombotic conditions (26.4%), mainly methylenetetrahydrofolate reductase mutation (6.3%) and Factor V Leiden mutation (5.1%), were the most common etiologies in both genders. 8.1% of patients had infection-associated and 5.2% had malignancy-related etiology that was significantly higher in men and older age group. Parenchymal involvement constitutively hemorrhagic infarcts, malignancy, and older age was associated with higher Rankin score. Epileptic seizures had no effect on prognosis. Conclusions: Clinical and radiological findings were consistent with previous larger studies but predisposing factors were different with a higher incidence of puerperium. Oral contraceptive use was not a prevalent risk factor in our cohort. Malignancy, older age, and hemorrhagic infarcts had worse outcome. (c) 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jstrokecerebrovasdis.2017.04.020
dc.identifier.endpage1857en_US
dc.identifier.issn1052-3057
dc.identifier.issn1532-8511
dc.identifier.issue8en_US
dc.identifier.pmid28583818en_US
dc.identifier.scopus2-s2.0-85020109081en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1848en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.04.020
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8270
dc.identifier.volume26en_US
dc.identifier.wosWOS:000407019200036en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofJOURNAL OF STROKE & CEREBROVASCULAR DISEASESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY02044
dc.subjectCerebrovascular diseaseen_US
dc.subjectcerebral venous sinus thrombosisen_US
dc.subjectclinicen_US
dc.subjectimagingen_US
dc.titleA Multicenter Study of 1144 Patients with Cerebral Venous Thrombosis: The VENOST Studyen_US
dc.typeArticle
dspace.entity.typePublication

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