Tetanus and diphtheria immunity among term and preterm infant-mother pairs in Turkey, a country where maternal and neonatal tetanus have recently been eliminated

Basit Öğe Kaydı
dc.authorid0000-0001-8944-0659en_US
dc.contributor.authorErener-Ercan, Tugba
dc.contributor.authorAslan, Mustafa
dc.contributor.authorVural, Mehmet
dc.contributor.authorErginoz, Ethem
dc.contributor.authorKocazeybek, Bekir
dc.contributor.authorErcan, Gokmen
dc.contributor.authorTurkgeldi, Lale Wetherilt
dc.contributor.authorPerk, Yildiz
dc.date.accessioned2024-07-12T21:46:43Z
dc.date.available2024-07-12T21:46:43Z
dc.date.issued2015en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractThe aim of our study was to investigate the anti-tetanus and anti-diphtheria antibody titres and the placental transfer of these antibodies in a group of vaccinated and unvaccinated mothers and their term or preterm offsprings. Anti-tetanus and anti-diphtheria toxoid IgG antibodies were measured quantitatively by ELISA in 91 infant-mother pairs. Protective concentrations of anti-tetanus and anti-diphtheria were found in 58.3 and 50 % of mothers in the unvaccinated group and 94.5 and 85.5 % of the mothers in the vaccinated group. Protective concentrations were found in 63.9 and 50 % of cord samples, respectively, in the unvaccinated group and in 96.4 and 85.5 % of cord samples, respectively, in the vaccinated group (p = 0.0001). There were no differences in the maternal and cord geometric mean concentrations (GMCs) of anti-toxoid antibodies between those who received two doses or one dose of Td. The GMCs of maternal and cord anti-tetanus and anti-diphtheria were statistically similar between preterm and term groups. Placental transfer ratios (TR) for anti-tetanus and anti-diphtheria were 175 and 150 %, respectively, in the preterm group and 213 and 178 %, respectively, in the term group. There was a strong correlation between maternal and cord anti-toxoid antibody levels. Maternal vaccination was the only predictor of having protective concentrations of anti-toxoid antibodies in cord blood. Conclusions: Vaccinating pregnant women with at least one dose of Td would confer protection for both the term and preterm infant-mother pairs. Therefore, health personnel caring for pregnant women have the responsibility to emphasize the importance of Td vaccination to avoid missed immunization opportunities.en_US
dc.description.sponsorshipTurkish Pediatric Associationen_US
dc.description.sponsorshipWe thank Dr. Merve Eriksson for her support in gathering demographic information of the enrolled patients and in her assistance during the preparation and storage process of serum samples. We thank the Turkish Pediatric Association for their financial support in purchasing anti-toxoid ELISA kits.en_US
dc.identifier.doi10.1007/s00431-014-2400-9
dc.identifier.endpage344en_US
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.issue3en_US
dc.identifier.pmid25172444en_US
dc.identifier.scopus2-s2.0-84923339260en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage339en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00431-014-2400-9
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7957
dc.identifier.volume174en_US
dc.identifier.wosWOS:000350031800009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofEUROPEAN JOURNAL OF PEDIATRICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00871
dc.subjectTetanusen_US
dc.subjectDiphtheriaen_US
dc.subjectSeroprotectionen_US
dc.subjectMaternal vaccinationen_US
dc.subjectPretermen_US
dc.subjectTermen_US
dc.titleTetanus and diphtheria immunity among term and preterm infant-mother pairs in Turkey, a country where maternal and neonatal tetanus have recently been eliminateden_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu