The comparative evaluation of apoptosis produced by leuprolide or orchiectomy on rat prostate tissue

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dc.authorid0000-0001-5337-5226en_US
dc.authorid0000-0003-0395-1154en_US
dc.contributor.authorCakiroglu, Basri
dc.contributor.authorHazar, Aydin Ismet
dc.contributor.authorEyyupoglu, Seyit Erkan
dc.contributor.authorBalci, Mustafa Bahadir Can
dc.contributor.authorSinanoglu, Orhun
dc.contributor.authorTuzlali, Pinar
dc.date.accessioned2024-07-12T21:45:08Z
dc.date.available2024-07-12T21:45:08Z
dc.date.issued2015en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractIntroduction: Organisms are constantly in a balance meaning that while new cells are produced, some of the older ones die which takes place in 2 ways: necrosis or apoptosis. Apoptosis is the programmed cellular death triggered by intrinsic or extrinsic stimuli. In this study we have evaluated the apoptosis of prostate tissue generated by surgical or medical orchiectomy. Material and Method: In this experimental study, we used 36 adult male rats that were evaluated in 3 groups. The first group (Group 1) consisted of 12 rats that had bilateral orchiectomy; the second group (Group 2) included 12 rats that were given leuprolide acetate and the third group (Group 3) consisted of 12 control rats. Immunohistochemical staining of the prostate of all rats was performed and the presence of glandular atrophy and apoptosis were evaluated in the three groups. The statistical differences between the two groups were evaluated by the Fisher exact test. Results: Glandular atrophy was not determined in any rat of the control group, and the apoptotic staining was in the normal limits in all the control rats. In Leuprolide group, glandular atrophy was mild in 7 cases, and moderate in 3 rats. In 2 rats of the Leuprolide group, atrophy was not demonstrated. In surgical orchiectomy group, glandular atrophy was present in all cases. Atrophy was observed as cystic atrophy. Statistical analysis with the Fisher exact test revealed that glandular atrophy was statistically significantly more common in surgical orchiectomy group compared with Leuprolide group (p = 0,012). Conclusion: If the aim of treatment in androgen dependent prostatic adenocarcinoma or benign prostate hypertrophy is the construction of a robust apoptosis, bilateral orchiectomy generates a more powerful apoptosis compared with Leuprolide.en_US
dc.description.sponsorshipPathology Laboratory, Taksim Training and Research Hospitalen_US
dc.description.sponsorshipWe thank Pathology Laboratory, Taksim Training and Research Hospital for laboratory facilities, technical assistance and financial aid.en_US
dc.identifier.doi10.4081/aiua.2015.4.265
dc.identifier.endpage269en_US
dc.identifier.issn1124-3562
dc.identifier.issn2282-4197
dc.identifier.issue4en_US
dc.identifier.pmid26766795en_US
dc.identifier.scopus2-s2.0-84975062646en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage265en_US
dc.identifier.urihttps://dx.doi.org/10.4081/aiua.2015.4.265
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7801
dc.identifier.volume87en_US
dc.identifier.wosWOS:000440260900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPAGEPRESS PUBLen_US
dc.relation.ispartofARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00328
dc.subjectProstateen_US
dc.subjectOrchiectomyen_US
dc.subjectLeuprolideen_US
dc.subjectApoptosisen_US
dc.titleThe comparative evaluation of apoptosis produced by leuprolide or orchiectomy on rat prostate tissueen_US
dc.typeArticle
dspace.entity.typePublication

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