Efficacy of a Modified Sequential Therapy Including Bismuth Subcitrate as First-Line Therapy to Eradicate Helicobacter pylori in a Turkish Population

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dc.authorid0000-0002-0229-1695en_US
dc.contributor.authorUygun, Ahmet
dc.contributor.authorOzel, A. Melih
dc.contributor.authorSivri, Bulent
dc.contributor.authorPolat, Zulfikar
dc.contributor.authorGenc, Halil
dc.contributor.authorSakin, Yusuf Serdar
dc.contributor.authorCelebi, Gurkan
dc.contributor.authorUygur-Bayramicli, Oya
dc.contributor.authorErcin, Cemal Nuri
dc.contributor.authorKadayifci, Abdurrahman
dc.contributor.authorEmer, Ozdes
dc.contributor.authorGunal, Armagan
dc.contributor.authorBagci, Sait
dc.date.accessioned2024-07-12T21:47:18Z
dc.date.available2024-07-12T21:47:18Z
dc.date.issued2012en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground Eradication rates of Helicobacter pylori with standard triple therapy are not satisfactory. Sequential therapy is an alternative method to overcome this problem. Objectives The aim of this study was to assess efficacy of a modified sequential therapy with the addition of a bismuth preparation, as first-line treatment in the eradication of H. pylori infection. Materials and Methods One hundred and forty-two H. pylori-positive patients were included in the study. Patients were given a 14-day sequential therapy program consisting of pantoprazole, 40 mg (b.i.d. for 14 days); colloidal bismuth subcitrate, 300 mg 4 (two tablets before breakfast and dinner, for 14 days); amoxicillin, 1 g (b.i.d.for the first 7 days); tetracycline, 500 mg (q.i.d. for the second 7 days); and metronidazole, 500 mg (t.i.d. for the second 7 days). Eradication was tested by urea breath test (UBT) 6 weeks after completion of treatment. Results Of the 142 patients included, 131 completed the study. Per-protocol and intention-to-treat analyses revealed high eradication rates in this group (92.095% CI, 87.296.8%, and 81.095% CI, 74.587.4%, respectively). There was no relation to sex and age with this modified sequential therapy. Compliance was satisfactory (11 patients four women and seven men were unavailable for follow-up), and side effects were minimal (six patients had to stop treatment metronidazole-related facial swelling and numbness on the face and hands in two patients; tetracycline-related fever and epigastric pain and nausea and vomiting in two patients; and amoxicillin-related diarrhea and vaginal discharge in two patients). These side effects were reversible and resolved after the cessation of the related medication. Conclusions This 14-day modified sequential treatment, including bismuth, achieves a significantly high eradication rates in patients with H. pylori infection, with five satisfactory patient compliance and minor side effects.en_US
dc.identifier.doi10.1111/j.1523-5378.2012.00989.x
dc.identifier.endpage490en_US
dc.identifier.issn1083-4389
dc.identifier.issue6en_US
dc.identifier.pmid23067136en_US
dc.identifier.scopus2-s2.0-84867713594en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage486en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1523-5378.2012.00989.x
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8030
dc.identifier.volume17en_US
dc.identifier.wosWOS:000310319900011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofHELICOBACTERen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01184
dc.subjectHelicobacter pylorien_US
dc.subjectsequential therapyen_US
dc.subjectmodified treatmenten_US
dc.subjectbismuthen_US
dc.titleEfficacy of a Modified Sequential Therapy Including Bismuth Subcitrate as First-Line Therapy to Eradicate Helicobacter pylori in a Turkish Populationen_US
dc.typeArticle
dspace.entity.typePublication

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