Reperfusion strategy after regional ischaemia: Simulation of emergency revascularization and effects of integrated cardioplegia on myocardial resuscitation

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dc.contributor.authorUs, MH
dc.contributor.authorOgus, NT
dc.contributor.authorYildirim, T
dc.contributor.authorOgus, H
dc.contributor.authorOzkan, S
dc.contributor.authorOzturk, OY
dc.contributor.authorIsik, O
dc.date.accessioned2024-07-12T21:50:47Z
dc.date.available2024-07-12T21:50:47Z
dc.date.issued2004en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractWe induced ischaemia in the left anterior descending artery of 16 dogs while the heart was beating, followed by cardiopulmonary bypass (CPB), aortic cross clamping and blood cardioplegia. Half of the dogs received integrated blood cardioplegia and sudden uncontrolled reperfusion (group A) while the others received the same cardioplegia followed by pressure-controlled tepid initial reperfusion (group B). The effects on myocardial cell metabolism, oxidative stress and ultrastructure were recorded. The recovery period was significantly longer and cardiac output levels after CPB significantly lower in group A compared with group B. Group A showed a failure to uptake and utilize oxygen during the recovery period and significant lipid peroxidation. Marked tissue oedema was seen in group A but mitochondrial and organelle integrity was almost normal in both groups. We conclude that integrated cardioplegia could partially resuscitate the myocardium in this model, and pressure controlled reperfusion during the first 2 min is needed as an adjunct procedure.en_US
dc.identifier.doi10.1177/147323000403200310
dc.identifier.endpage311en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue3en_US
dc.identifier.pmid15174224en_US
dc.identifier.scopus2-s2.0-2442636651en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage304en_US
dc.identifier.urihttps://dx.doi.org/10.1177/147323000403200310
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8205
dc.identifier.volume32en_US
dc.identifier.wosWOS:000221459600010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofJOURNAL OF INTERNATIONAL MEDICAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01929
dc.subjectemergencyen_US
dc.subjectischaemiaen_US
dc.subjectrevascularizationen_US
dc.subjectreperfusionen_US
dc.subjectcontrolen_US
dc.subjectoedemaen_US
dc.titleReperfusion strategy after regional ischaemia: Simulation of emergency revascularization and effects of integrated cardioplegia on myocardial resuscitationen_US
dc.typeArticle
dspace.entity.typePublication

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