The Effects of Difumarate Salt S-15176 after Spinal Cord Injury in Rats

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dc.authorid0000-0002-5300-4449en_US
dc.authorid0000-0002-8313-4092en_US
dc.authorid0000-0002-4713-4271en_US
dc.contributor.authorErdogan, Hakan
dc.contributor.authorTuncdemir, Matem
dc.contributor.authorKelten, Bilal
dc.contributor.authorAkdemir, Osman
dc.contributor.authorKaraoglan, Alper
dc.contributor.authorTasdemiroglu, Erol
dc.date.accessioned2024-07-12T21:50:50Z
dc.date.available2024-07-12T21:50:50Z
dc.date.issued2015en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjective : In the present study we analyzed neuroprotective and antiapoptotic effect of the difumarate salt S-15176, as an anti-ischemic, an antioxidant and a stabilizer of mitochondrial membrane in secondary damage following spinal cord injury (SCI) in a rat model. Methods : Three groups were performed with 30 Wistar rats; control (1), trauma (2), and a trauma+S-15176 (10 mg/kg i.p., dimethyl sulfoxide) treatment (3). SCI was performed at the thoracic level using the weight-drop technique. Spinal cord tissues were collected following intracardiac perfusion in 3rd and 7th days of posttrauma. Hematoxylin and eosin staining for histopatology, terminal deoxynucleotidyl transferase dUTP nick end labeling assay for apoptotic cells and immunohistochemistry for proapoptotic cytochrome-c, Bax and caspase 9 were performed to all groups. Functional recovery test were applied to each group in 3rd and 7th days following SCI. Results : In trauma group, edematous regions, diffuse hemorrhage, necrosis, leukocyte infiltration and severe degeneration in motor neurons were observed prominently in gray matter. The number of apoptotic cells was significantly higher (p<0.05) than control group. In the S-15176-treated groups, apoptotic cell number in 3rd and 7th days (p<0.001), also cytochrome-c (p<0.001), Box (p<0.001) and caspase 9 immunoreactive cells (p<0.001) were significantly decreased in number compared to trauma groups. Hemorrhage and edema in the focal areas were also noticed in gray matter of treatment groups. Results of the locomotor test were significantly increased in treatment group (p<0.05) when compared to trauma groups. Conclusion : We suggest that difumarate salt S-15176 prevents mitochondrial pathways of apoptosis and protects spinal cord from secondary injury and helps to preserve motor function following SCI in rats.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University [UDP-18761]en_US
dc.description.sponsorshipThis work was supported by Scientific Research Projects Coordination Unit of Istanbul University, project number UDP-18761.en_US
dc.identifier.doi10.3340/jkns.2015.57.6.445
dc.identifier.endpage454en_US
dc.identifier.issn2005-3711
dc.identifier.issn1598-7876
dc.identifier.issue6en_US
dc.identifier.pmid26180614en_US
dc.identifier.scopus2-s2.0-84936745575en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage445en_US
dc.identifier.urihttps://dx.doi.org/10.3340/jkns.2015.57.6.445
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8211
dc.identifier.volume57en_US
dc.identifier.wosWOS:000357553800012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKOREAN NEUROSURGICAL SOCen_US
dc.relation.ispartofJOURNAL OF KOREAN NEUROSURGICAL SOCIETYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY01947
dc.subjectDifumarate salt (S-15176)en_US
dc.subjectSpinal cord Injuryen_US
dc.subjectCytochrome-cen_US
dc.subjectCaspase-9en_US
dc.subjectApoptosisen_US
dc.titleThe Effects of Difumarate Salt S-15176 after Spinal Cord Injury in Ratsen_US
dc.typeArticle
dspace.entity.typePublication

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