Sternal cyanoacrylate gluing in mediastinitis - Effects on infection, stability and bone healing

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dc.contributor.authorOgus, TN
dc.contributor.authorUs, MH
dc.contributor.authorCicek, S
dc.contributor.authorOzkan, S
dc.contributor.authorOzturk, OY
dc.contributor.authorIsic, O
dc.date.accessioned2024-07-12T21:50:19Z
dc.date.available2024-07-12T21:50:19Z
dc.date.issued2002en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground It is crucial to determine stability, histocompatibility and antibacterial properties of the cyanoacrylate used for sternal fixation. Methods. Clinical study: in 17 cases of mediastinitis, debridement and rewiring the sternum, was applied as the treatment method (Group I). Eighteen cases of mediastinitis were treated with the same method added sternal cyanoacrylate gluing (Group 11). A comparative study was done;, the follow-up period was 36.7 +/- 4 and 18.5 +/- 6.9 months in Group I and H, respectively. Animal study: in 10 rats, upper sternotomy was done and the sternal bone was contaminated. Direct wound closure was done in 4 rats (Group A), in 6 animals, wounds were dosed after applying cyanoacrylate in sternal split (Group B). in this prospective study, all rats alive were sacrificed at the 3rd and 8th weeks and sternums were examined histologically. Results. Clinical study: in Group 1, 6 patients required additional interventions due to recurrent sternal detachment and osteomyelitis (35.3%). In Group H neither osteomyelitis nor sternal detachment occurred, 3 patients required re-intervention related to cyanoacrylate histotoxicity. Hospital stay was higher in Group I than Group II (24.06 +/- 4.7 vs 14.16 +/- 3.98 days, respectively). Experimental study: all of the animals in Group A died of sepsis. In Group B all rats survived the procedure. At the 3rd week histologic evaluations showed that cyanoacrylate was not degraded, and no infection or foreign body reaction was observed. At the 8th week histologic examination showed that cyanoacrylate was completely degraded and replaced by connective tissue. Conclusions. Cyanoacrylate is effective in diminishing sternal wound complications and related cost and hospital stay of mediastinitis.en_US
dc.identifier.endpage746en_US
dc.identifier.issn0021-9509
dc.identifier.issue5en_US
dc.identifier.pmid12386595en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage741en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8149
dc.identifier.volume43en_US
dc.identifier.wosWOS:000179581300029en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherEDIZIONI MINERVA MEDICAen_US
dc.relation.ispartofJOURNAL OF CARDIOVASCULAR SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01820
dc.subjectcyanoacrylatesen_US
dc.subjectbiocompatible materialsen_US
dc.subjectosteomyelitisen_US
dc.subjectmediastinitis, surgeryen_US
dc.subjectsternum, surgeryen_US
dc.titleSternal cyanoacrylate gluing in mediastinitis - Effects on infection, stability and bone healingen_US
dc.typeArticle
dspace.entity.typePublication

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