Immunohistochemical demonstration of cytochrome oxidase in different parts of the central nervous system: a comparative experimental study

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dc.authorid0000-0001-6317-4719en_US
dc.authorid0000-0002-4474-7371en_US
dc.contributor.authorTaşkınalp, Oğuz
dc.contributor.authorCığalı, Bülent Sabri
dc.contributor.authorKutlu, A. K.
dc.date.accessioned2024-07-12T21:01:35Z
dc.date.available2024-07-12T21:01:35Z
dc.date.issued2008en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractCytochrome oxidase, the terminal enzyme of the electron transport chain, is a marker of the functional activity of the cell. In this study; localization of cytochrome oxidase in cerebrum, cerebellum, hippocampus, substantia nigra and choroid plexus of adult rats was investigated using immunohistochemical methods. Neural bodies were immunoreactive while neuroglial cells and axonal areas did not show significant immunostaining. The cerebral cortical substantia grisea region was stained almost homogeneously with cytochrome oxidase. In the cerebellar cortex, immunolabelling was more intense in the granular layer than the molecular layer. There was significant immunostaining in Purkinje cells. White matter, both in cerebrum and cerebellum, did not show immunoreactivity for cytochrome oxidase. Neurones in the hippocampus showed variable immunostaining; some of them were negative while others revealed high immunoreactivity. The neurones in substantia nigra were heavily labelled. Immunostaining for cytochrome oxidase in plexus choroideus epithelial cells was also remarkable. The morphological findings demonstrate the regions which most require and produce energy and reflect the differences in cellular activity in these parts of the central nervous system.en_US
dc.identifier.citationTaşkınalp, O., Aktaş, R.G., Cığalı, B. S. ve Kutlu, A. K. (2008). Immunohistochemical demonstration of cytochrome oxidase in different parts of the central nervous system: a comparative experimental study. Anatomia, Histologia, Embryologia, Wiley. 29(6), s. 345-349.en_US
dc.identifier.endpage349en_US
dc.identifier.issn1439-0264
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage345en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1046/j.1439-0264.2000.00281.x
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3518
dc.identifier.volume29en_US
dc.institutionauthorAktas, Ranan Gulhan
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAnatomia, Histologia, Embryologiaen_US
dc.relation.isversionof10.1046/j.1439-0264.2000.00281.xen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY00220
dc.titleImmunohistochemical demonstration of cytochrome oxidase in different parts of the central nervous system: a comparative experimental studyen_US
dc.typeArticle
dspace.entity.typePublication

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